Malignant lymphoma of mucosa-associated lymphoid tissue involving the renal pelvis and the entire ureter: A case report

Hideo Otsuki, Keiichi Ito, Ken Sato, Takeo Kosaka, Hideyuki Shimazaki, Tatsumi Kaji, Tomohiko Asano

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Mucosa-associated lymphoid tissue (MALT) lymphoma occurs in various sites, but rarely in the urinary tract. Imaging studies of a 69-year-old male revealed a left hydronephrosis and diffuse thickening of the renal pelvic and upper ureteral wall. Retrograde pyelography revealed a narrowing in this region, and brush cytology specimens contained atypical cells. As the lesion was considered to be malignant, surgical excision was performed. Histological analysis revealed an intense lymphoid infiltrate mainly consisting of B cells. The immunohistochemistry results demonstrated that the lesion was positive for CD20 and CD79a and negative for CD5 and cyclin D1. These findings led to a diagnosis of MALT lymphoma. Pathological exploration disclosed a focally dense invasion of lymphoma cells into not only the renal pelvis, but the whole ureteral wall and surrounding tissue; therefore, the patient underwent eight courses of rituximab treatment. Diffuse invasion of lymphoma cells into the whole ureter was rarely observed. Since the surgery, the patient has survived for 78 months without evidence of a recurrence of lymphoma.

Original languageEnglish
Pages (from-to)1625-1628
Number of pages4
JournalOncology Letters
Volume5
Issue number5
DOIs
Publication statusPublished - 2013 Oct
Externally publishedYes

Fingerprint

Marginal Zone B-Cell Lymphoma
Kidney Pelvis
Ureter
Lymphoma
Hydronephrosis
Urography
Cyclin D1
Urinary Tract
Non-Hodgkin's Lymphoma
Cell Biology
B-Lymphocytes
Immunohistochemistry
Kidney
Recurrence
Therapeutics

Keywords

  • Mucosa-associated lymphoid tissue lymphoma
  • Nephroureterectomy
  • Rituximab
  • Upper urinary tract
  • Ureteral wall thickening

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Malignant lymphoma of mucosa-associated lymphoid tissue involving the renal pelvis and the entire ureter : A case report. / Otsuki, Hideo; Ito, Keiichi; Sato, Ken; Kosaka, Takeo; Shimazaki, Hideyuki; Kaji, Tatsumi; Asano, Tomohiko.

In: Oncology Letters, Vol. 5, No. 5, 10.2013, p. 1625-1628.

Research output: Contribution to journalArticle

Otsuki, Hideo ; Ito, Keiichi ; Sato, Ken ; Kosaka, Takeo ; Shimazaki, Hideyuki ; Kaji, Tatsumi ; Asano, Tomohiko. / Malignant lymphoma of mucosa-associated lymphoid tissue involving the renal pelvis and the entire ureter : A case report. In: Oncology Letters. 2013 ; Vol. 5, No. 5. pp. 1625-1628.
@article{17ac48d66d604c6db4360f9f88949673,
title = "Malignant lymphoma of mucosa-associated lymphoid tissue involving the renal pelvis and the entire ureter: A case report",
abstract = "Mucosa-associated lymphoid tissue (MALT) lymphoma occurs in various sites, but rarely in the urinary tract. Imaging studies of a 69-year-old male revealed a left hydronephrosis and diffuse thickening of the renal pelvic and upper ureteral wall. Retrograde pyelography revealed a narrowing in this region, and brush cytology specimens contained atypical cells. As the lesion was considered to be malignant, surgical excision was performed. Histological analysis revealed an intense lymphoid infiltrate mainly consisting of B cells. The immunohistochemistry results demonstrated that the lesion was positive for CD20 and CD79a and negative for CD5 and cyclin D1. These findings led to a diagnosis of MALT lymphoma. Pathological exploration disclosed a focally dense invasion of lymphoma cells into not only the renal pelvis, but the whole ureteral wall and surrounding tissue; therefore, the patient underwent eight courses of rituximab treatment. Diffuse invasion of lymphoma cells into the whole ureter was rarely observed. Since the surgery, the patient has survived for 78 months without evidence of a recurrence of lymphoma.",
keywords = "Mucosa-associated lymphoid tissue lymphoma, Nephroureterectomy, Rituximab, Upper urinary tract, Ureteral wall thickening",
author = "Hideo Otsuki and Keiichi Ito and Ken Sato and Takeo Kosaka and Hideyuki Shimazaki and Tatsumi Kaji and Tomohiko Asano",
year = "2013",
month = "10",
doi = "10.3892/ol.2013.1221",
language = "English",
volume = "5",
pages = "1625--1628",
journal = "Oncology Letters",
issn = "1792-1074",
publisher = "Spandidos Publications",
number = "5",

}

TY - JOUR

T1 - Malignant lymphoma of mucosa-associated lymphoid tissue involving the renal pelvis and the entire ureter

T2 - A case report

AU - Otsuki, Hideo

AU - Ito, Keiichi

AU - Sato, Ken

AU - Kosaka, Takeo

AU - Shimazaki, Hideyuki

AU - Kaji, Tatsumi

AU - Asano, Tomohiko

PY - 2013/10

Y1 - 2013/10

N2 - Mucosa-associated lymphoid tissue (MALT) lymphoma occurs in various sites, but rarely in the urinary tract. Imaging studies of a 69-year-old male revealed a left hydronephrosis and diffuse thickening of the renal pelvic and upper ureteral wall. Retrograde pyelography revealed a narrowing in this region, and brush cytology specimens contained atypical cells. As the lesion was considered to be malignant, surgical excision was performed. Histological analysis revealed an intense lymphoid infiltrate mainly consisting of B cells. The immunohistochemistry results demonstrated that the lesion was positive for CD20 and CD79a and negative for CD5 and cyclin D1. These findings led to a diagnosis of MALT lymphoma. Pathological exploration disclosed a focally dense invasion of lymphoma cells into not only the renal pelvis, but the whole ureteral wall and surrounding tissue; therefore, the patient underwent eight courses of rituximab treatment. Diffuse invasion of lymphoma cells into the whole ureter was rarely observed. Since the surgery, the patient has survived for 78 months without evidence of a recurrence of lymphoma.

AB - Mucosa-associated lymphoid tissue (MALT) lymphoma occurs in various sites, but rarely in the urinary tract. Imaging studies of a 69-year-old male revealed a left hydronephrosis and diffuse thickening of the renal pelvic and upper ureteral wall. Retrograde pyelography revealed a narrowing in this region, and brush cytology specimens contained atypical cells. As the lesion was considered to be malignant, surgical excision was performed. Histological analysis revealed an intense lymphoid infiltrate mainly consisting of B cells. The immunohistochemistry results demonstrated that the lesion was positive for CD20 and CD79a and negative for CD5 and cyclin D1. These findings led to a diagnosis of MALT lymphoma. Pathological exploration disclosed a focally dense invasion of lymphoma cells into not only the renal pelvis, but the whole ureteral wall and surrounding tissue; therefore, the patient underwent eight courses of rituximab treatment. Diffuse invasion of lymphoma cells into the whole ureter was rarely observed. Since the surgery, the patient has survived for 78 months without evidence of a recurrence of lymphoma.

KW - Mucosa-associated lymphoid tissue lymphoma

KW - Nephroureterectomy

KW - Rituximab

KW - Upper urinary tract

KW - Ureteral wall thickening

UR - http://www.scopus.com/inward/record.url?scp=84875757559&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875757559&partnerID=8YFLogxK

U2 - 10.3892/ol.2013.1221

DO - 10.3892/ol.2013.1221

M3 - Article

AN - SCOPUS:84875757559

VL - 5

SP - 1625

EP - 1628

JO - Oncology Letters

JF - Oncology Letters

SN - 1792-1074

IS - 5

ER -