Mammalian BarH homologue is a potential regulator of neural bHLH genes

Tetsuichiro Saito, Kazunobu Sawamoto, Hideyuki Okano, David J. Anderson, Katsuhiko Mikoshiba

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Vertebrate neurogenesis involves sequential actions of transcription factors. neurogenins, encoding Atonal-related bHLH transcription factors, function as neuronal determination genes in Xenopus. neurogenins and another bHLH factor gene, Mash1, are expressed in distinct subsets or areas of cells giving rise to neurons, suggesting that these genes play important roles to generate distinct populations of neurons. A mammalian homologue of BarH (MBH1) is expressed in a complementary pattern to Mash1 expression in the developing nervous system like neurogenins. Forced expression of MBH1 down- regulates expression of Mash1 and up-regulates neurogenin2/Math4A, a member of neurogenins, in P19 cells during neuronal differentiation. This suggests that MBH1 is a potential regulator of mammalian neural bHLH genes, thereby establishing distinct pathways of neuronal differentiation.

Original languageEnglish
Pages (from-to)216-225
Number of pages10
JournalDevelopmental Biology
Volume199
Issue number2
DOIs
Publication statusPublished - 1998 Jul 15
Externally publishedYes

ASJC Scopus subject areas

  • Molecular Biology
  • Developmental Biology
  • Cell Biology

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