Abstract
Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and its mammalian homolog is expressed in a variety of differentiating tissues. Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinoic acid receptor and activation transcription factor-2 (ATF-2). In addition, antisense oligonucleotide treatment of embryonic mouse lung explants suggests that Rcdl also plays a role in retinoic acid-controlled lung development.
| Original language | English |
|---|---|
| Pages (from-to) | 5235-5244 |
| Number of pages | 10 |
| Journal | EMBO Journal |
| Volume | 21 |
| Issue number | 19 |
| DOIs | |
| Publication status | Published - 2002 Oct 1 |
| Externally published | Yes |
Keywords
- Development
- Differentiation
- F9
- Retinoic acid
- Transcription
ASJC Scopus subject areas
- Neuroscience(all)
- Molecular Biology
- Biochemistry, Genetics and Molecular Biology(all)
- Immunology and Microbiology(all)