Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation

Noriko Hiroi, Takaaki Ito, Hanako Yamamoto, Takahiro Ochiya, Shigeki Jinno, Hiroto Okayama

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and its mammalian homolog is expressed in a variety of differentiating tissues. Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinoic acid receptor and activation transcription factor-2 (ATF-2). In addition, antisense oligonucleotide treatment of embryonic mouse lung explants suggests that Rcdl also plays a role in retinoic acid-controlled lung development.

Original languageEnglish
Pages (from-to)5235-5244
Number of pages10
JournalEMBO Journal
Volume21
Issue number19
DOIs
Publication statusPublished - 2002 Oct 1
Externally publishedYes

Fingerprint

Tretinoin
Cell Differentiation
Teratocarcinoma
Lung
Retinoic Acid Receptors
Schizosaccharomyces
Antisense Oligonucleotides
Starvation
Eukaryota
Yeast
Transcription Factors
Nitrogen
Chemical activation
Tissue
Proteins

Keywords

  • Development
  • Differentiation
  • F9
  • Retinoic acid
  • Transcription

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation. / Hiroi, Noriko; Ito, Takaaki; Yamamoto, Hanako; Ochiya, Takahiro; Jinno, Shigeki; Okayama, Hiroto.

In: EMBO Journal, Vol. 21, No. 19, 01.10.2002, p. 5235-5244.

Research output: Contribution to journalArticle

Hiroi, N, Ito, T, Yamamoto, H, Ochiya, T, Jinno, S & Okayama, H 2002, 'Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation', EMBO Journal, vol. 21, no. 19, pp. 5235-5244. https://doi.org/10.1093/emboj/cdf521
Hiroi, Noriko ; Ito, Takaaki ; Yamamoto, Hanako ; Ochiya, Takahiro ; Jinno, Shigeki ; Okayama, Hiroto. / Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation. In: EMBO Journal. 2002 ; Vol. 21, No. 19. pp. 5235-5244.
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