Mammalian Rcd1 is a novel transcriptional cofactor that mediates retinoic acid-induced cell differentiation

Noriko Hiroi, Takaaki Ito, Hanako Yamamoto, Takahiro Ochiya, Shigeki Jinno, Hiroto Okayama

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Rcd1, initially identified as a factor essential for the commitment to nitrogen starvation-invoked differentiation in fission yeast, is one of the most conserved proteins found across eukaryotes, and its mammalian homolog is expressed in a variety of differentiating tissues. Here we show that mammalian Rcd1 is a novel transcriptional cofactor and is critically involved in the commitment step in the retinoic acid-induced differentiation of F9 mouse teratocarcinoma cells, at least in part, via forming complexes with retinoic acid receptor and activation transcription factor-2 (ATF-2). In addition, antisense oligonucleotide treatment of embryonic mouse lung explants suggests that Rcdl also plays a role in retinoic acid-controlled lung development.

Original languageEnglish
Pages (from-to)5235-5244
Number of pages10
JournalEMBO Journal
Volume21
Issue number19
DOIs
Publication statusPublished - 2002 Oct 1

Keywords

  • Development
  • Differentiation
  • F9
  • Retinoic acid
  • Transcription

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

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