Management and outcomes of hydronephrosis in patients with metastatic extramammary Paget’s disease: A retrospective analysis

Takayuki Fusumae, Keitaro Fukuda, Ikuko Hirai, Yoshio Nakamura, Kenta Kobayashi, Keiji Tanese, Kazuhiro Matsumoto, Takashi Iwata, Takeru Funakoshi

Research output: Contribution to journalArticlepeer-review

Abstract

Hydronephrosis in extramammary Paget’s disease (EMPD) with distant metastasis (metastatic EMPD) has been observed in medical practice; however, its prognosis remains unclear. Retrospective analyses were performed to assess the management and outcomes of hydronephrosis in metastatic EMPD. During a follow-up of 44 patients with metastatic EMPD, 13 (30%) developed hydronephrosis. Ten (77%) of the 13 patients with hydronephrosis had impaired renal function (estimated glomerular filtration rate: <60 ml/min/1.73 m2), and ureteral stents were placed in every patient with impaired renal function. The stent was placed successfully in all 10 patients, and their renal function recovered within a median period of 7 days. Importantly, each of these patients continued chemotherapy, and none of them experienced stent failure. The median overall survival time (OS) in patients with metastatic EMPD and hydronephrosis (n = 13) was 7.8 months. Treatment for hydronephrosis was not a significant factor for OS, and median OS in patients who underwent ureteral stent replacement (n = 10) was 14.7 months. Collectively, our results indicate that hydronephrosis is relatively common, and ureteral stent placement should be considered in cases of metastatic EMPD with hydronephrosis to maintain renal function and continue chemotherapy toward a better prognosis.

Original languageEnglish
JournalJournal of Dermatology
DOIs
Publication statusAccepted/In press - 2022

Keywords

  • hydronephrosis
  • impaired renal function
  • malignant ureteral obstruction
  • metastatic extramammary Paget’s disease
  • ureteral stent

ASJC Scopus subject areas

  • Dermatology

Fingerprint

Dive into the research topics of 'Management and outcomes of hydronephrosis in patients with metastatic extramammary Paget’s disease: A retrospective analysis'. Together they form a unique fingerprint.

Cite this