Manifestations mimicking relapsing polychondritis in a patient with microscopic polyangiitis

Hiroe Ogawa, Eiko Nishi, Hideto Kameda, Koichi Amano, Tsutomu Takeuchi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Microscopic polyangiitis (MPA) is a systemic disorder characterized by inflammation of small vessels mainly affecting the kidneys and lungs. We describe a 72-year-old woman who developed multiple cartilage involvements as well as major manifestations of MPA. The left ear biopsy demonstrated cartilaginous inflammation and small vessel vasculitis. She also had conjunctivitis, hearing impairment, interstitial lung disease, glomerulonephritis with vasculitis and mononeuritis multiplex. Serological examinations revealed a positive antineutrophil cytoplasmic antibody (PR-3 ANCA). Cyclophosphamide and oral corticosteroid therapy was instituted and remission achieved. Due to lacks of nasal and bronchial involvements, as well as the evidence of auricular vasculitis, we concluded that her findings mimicking relapsing polychondritis developed as systemic manifestations of MPA.

Original languageEnglish
Pages (from-to)104-108
Number of pages5
JournalJapanese Journal of Clinical Immunology
Volume28
Issue number2
DOIs
Publication statusPublished - 2005 Jan 1
Externally publishedYes

Keywords

  • PR-3 ANCA
  • cartilage inflammation
  • cyclophosphamide
  • microscopic polyangiitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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