Manipulating cell fate in the cochlea: A feasible therapy for hearing loss

Masato Fujioka, Hideyuki Okano, Albert S B Edge

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is permanent and intractable. Recent studies in the mouse have demonstrated spontaneous hair cell regeneration during a short postnatal period, but this regenerative capacity is lost in the adult cochlea. Reduced regeneration coincides with a transition that results in a decreased pool of progenitor cells in the cochlear sensory epithelium. Here, we review the signaling cascades involved in hair cell formation and morphogenesis of the organ of Corti in developing mammals, the changing status of progenitor cells in the cochlea, and the regeneration of auditory hair cells in adult mammals.

Original languageEnglish
Pages (from-to)139-144
Number of pages6
JournalTrends in Neurosciences
Volume38
Issue number3
DOIs
Publication statusPublished - 2015 Mar 1

Fingerprint

Cochlea
Hearing Loss
Auditory Hair Cells
Regeneration
Mammals
Stem Cells
Organ of Corti
Alopecia
Therapeutics
Morphogenesis
Birds
Vertebrates
Fishes
Epithelium

Keywords

  • Cell replacement
  • Hair cells
  • Hearing loss
  • Sensory systems

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Manipulating cell fate in the cochlea : A feasible therapy for hearing loss. / Fujioka, Masato; Okano, Hideyuki; Edge, Albert S B.

In: Trends in Neurosciences, Vol. 38, No. 3, 01.03.2015, p. 139-144.

Research output: Contribution to journalArticle

@article{7e74e1bea5b548579361fd3001b320ff,
title = "Manipulating cell fate in the cochlea: A feasible therapy for hearing loss",
abstract = "Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is permanent and intractable. Recent studies in the mouse have demonstrated spontaneous hair cell regeneration during a short postnatal period, but this regenerative capacity is lost in the adult cochlea. Reduced regeneration coincides with a transition that results in a decreased pool of progenitor cells in the cochlear sensory epithelium. Here, we review the signaling cascades involved in hair cell formation and morphogenesis of the organ of Corti in developing mammals, the changing status of progenitor cells in the cochlea, and the regeneration of auditory hair cells in adult mammals.",
keywords = "Cell replacement, Hair cells, Hearing loss, Sensory systems",
author = "Masato Fujioka and Hideyuki Okano and Edge, {Albert S B}",
year = "2015",
month = "3",
day = "1",
doi = "10.1016/j.tins.2014.12.004",
language = "English",
volume = "38",
pages = "139--144",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "3",

}

TY - JOUR

T1 - Manipulating cell fate in the cochlea

T2 - A feasible therapy for hearing loss

AU - Fujioka, Masato

AU - Okano, Hideyuki

AU - Edge, Albert S B

PY - 2015/3/1

Y1 - 2015/3/1

N2 - Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is permanent and intractable. Recent studies in the mouse have demonstrated spontaneous hair cell regeneration during a short postnatal period, but this regenerative capacity is lost in the adult cochlea. Reduced regeneration coincides with a transition that results in a decreased pool of progenitor cells in the cochlear sensory epithelium. Here, we review the signaling cascades involved in hair cell formation and morphogenesis of the organ of Corti in developing mammals, the changing status of progenitor cells in the cochlea, and the regeneration of auditory hair cells in adult mammals.

AB - Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is permanent and intractable. Recent studies in the mouse have demonstrated spontaneous hair cell regeneration during a short postnatal period, but this regenerative capacity is lost in the adult cochlea. Reduced regeneration coincides with a transition that results in a decreased pool of progenitor cells in the cochlear sensory epithelium. Here, we review the signaling cascades involved in hair cell formation and morphogenesis of the organ of Corti in developing mammals, the changing status of progenitor cells in the cochlea, and the regeneration of auditory hair cells in adult mammals.

KW - Cell replacement

KW - Hair cells

KW - Hearing loss

KW - Sensory systems

UR - http://www.scopus.com/inward/record.url?scp=84924571455&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84924571455&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2014.12.004

DO - 10.1016/j.tins.2014.12.004

M3 - Article

C2 - 25593106

AN - SCOPUS:84924571455

VL - 38

SP - 139

EP - 144

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 3

ER -