TY - JOUR
T1 - Manipulating cell fate in the cochlea
T2 - A feasible therapy for hearing loss
AU - Fujioka, Masato
AU - Okano, Hideyuki
AU - Edge, Albert S.B.
N1 - Funding Information:
We are grateful to T. Nagai for his excellent technical assistance in the electron microscopy. This work was supported by MEXT. KAKENHI (Grant-in-Aid for Scientific Research (C), 24592560), by MHLW (Comprehensive Research on Disability Health and Welfare), by Takeda Science Foundation to M.F, and by NIH grants RO1 DC007174, R21 DC010440, and P30 DC05209.
Publisher Copyright:
© 2014 Elsevier Ltd.
PY - 2015/3/1
Y1 - 2015/3/1
N2 - Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is permanent and intractable. Recent studies in the mouse have demonstrated spontaneous hair cell regeneration during a short postnatal period, but this regenerative capacity is lost in the adult cochlea. Reduced regeneration coincides with a transition that results in a decreased pool of progenitor cells in the cochlear sensory epithelium. Here, we review the signaling cascades involved in hair cell formation and morphogenesis of the organ of Corti in developing mammals, the changing status of progenitor cells in the cochlea, and the regeneration of auditory hair cells in adult mammals.
AB - Mammalian auditory hair cells do not spontaneously regenerate, unlike hair cells in lower vertebrates, including fish and birds. In mammals, hearing loss due to the loss of hair cells is permanent and intractable. Recent studies in the mouse have demonstrated spontaneous hair cell regeneration during a short postnatal period, but this regenerative capacity is lost in the adult cochlea. Reduced regeneration coincides with a transition that results in a decreased pool of progenitor cells in the cochlear sensory epithelium. Here, we review the signaling cascades involved in hair cell formation and morphogenesis of the organ of Corti in developing mammals, the changing status of progenitor cells in the cochlea, and the regeneration of auditory hair cells in adult mammals.
KW - Cell replacement
KW - Hair cells
KW - Hearing loss
KW - Sensory systems
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U2 - 10.1016/j.tins.2014.12.004
DO - 10.1016/j.tins.2014.12.004
M3 - Review article
C2 - 25593106
AN - SCOPUS:84924571455
VL - 38
SP - 139
EP - 144
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 3
ER -