Marine natural products: A source of novel anticancer drugs

Shaden A.M. Khalifa; Nizar Elias; Mohamed A. Farag; Lei Chen; Aamer Saeed; Mohamed Elamir F. Hegazy; Moustafa S. Moustafa; Aida Abd El-Wahed; Saleh M. Al-Mousawi; Syed G. Musharraf; Fang Rong Chang; Arihiro Iwasaki; Kiyotake Suenaga; Muaaz Alajlani; Ulf Göransson; Hesham R. El-Seedi

doi:10.3390/md17090491

Marine natural products: A source of novel anticancer drugs

Shaden A.M. Khalifa, Nizar Elias, Mohamed A. Farag, Lei Chen, Aamer Saeed, Mohamed Elamir F. Hegazy, Moustafa S. Moustafa, Aida Abd El-Wahed, Saleh M. Al-Mousawi, Syed G. Musharraf, Fang Rong Chang, Arihiro Iwasaki, Kiyotake Suenaga, Muaaz Alajlani, Ulf Göransson, Hesham R. El-Seedi

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

246 Citations (Scopus)

Abstract

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

Original language	English
Article number	491
Journal	Marine Drugs
Volume	17
Issue number	9
DOIs	https://doi.org/10.3390/md17090491
Publication status	Published - 2019 Aug 23

Keywords

Anticancer
Antitumor
Clinical trials
Cytotoxic
Drugs
Marine
Microorganism
Plants

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md17090491

Cite this

Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M. E. F., Moustafa, M. S., El-Wahed, A. A., Al-Mousawi, S. M., Musharraf, S. G., Chang, F. R., Iwasaki, A., Suenaga, K., Alajlani, M., Göransson, U., & El-Seedi, H. R. (2019). Marine natural products: A source of novel anticancer drugs. Marine Drugs, 17(9), [491]. https://doi.org/10.3390/md17090491

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abstract = "Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.",

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author = "Khalifa, {Shaden A.M.} and Nizar Elias and Farag, {Mohamed A.} and Lei Chen and Aamer Saeed and Hegazy, {Mohamed Elamir F.} and Moustafa, {Moustafa S.} and El-Wahed, {Aida Abd} and Al-Mousawi, {Saleh M.} and Musharraf, {Syed G.} and Chang, {Fang Rong} and Arihiro Iwasaki and Kiyotake Suenaga and Muaaz Alajlani and Ulf G{\"o}ransson and El-Seedi, {Hesham R.}",

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doi = "10.3390/md17090491",

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AU - Khalifa, Shaden A.M.

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AU - Saeed, Aamer

AU - Hegazy, Mohamed Elamir F.

AU - Moustafa, Moustafa S.

AU - El-Wahed, Aida Abd

AU - Al-Mousawi, Saleh M.

AU - Musharraf, Syed G.

AU - Chang, Fang Rong

AU - Iwasaki, Arihiro

AU - Suenaga, Kiyotake

AU - Alajlani, Muaaz

AU - Göransson, Ulf

AU - El-Seedi, Hesham R.

PY - 2019/8/23

Y1 - 2019/8/23

N2 - Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

AB - Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

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KW - Antitumor

KW - Clinical trials

KW - Cytotoxic

KW - Drugs

KW - Marine

KW - Microorganism

KW - Plants

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ER -

Marine natural products: A source of novel anticancer drugs

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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