Marine natural products: A source of novel anticancer drugs

Shaden A.M. Khalifa, Nizar Elias, Mohamed A. Farag, Lei Chen, Aamer Saeed, Mohamed Elamir F. Hegazy, Moustafa S. Moustafa, Aida Abd El-Wahed, Saleh M. Al-Mousawi, Syed G. Musharraf, Fang Rong Chang, Arihiro Iwasaki, Kiyotake Suenaga, Muaaz Alajlani, Ulf Göransson, Hesham R. El-Seedi

Research output: Contribution to journalReview article

Abstract

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

Original languageEnglish
Article number491
JournalMarine Drugs
Volume17
Issue number9
DOIs
Publication statusPublished - 2019 Aug 23

Fingerprint

Aquatic Organisms
Biological Products
Pharmaceutical Preparations
Neoplasms
Anthozoa
Actinobacteria
Porifera
Fungi
Apoptosis
Bacteria
Research
Population
Therapeutics

Keywords

  • Anticancer
  • Antitumor
  • Clinical trials
  • Cytotoxic
  • Drugs
  • Marine
  • Microorganism
  • Plants

ASJC Scopus subject areas

  • Drug Discovery

Cite this

Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M. E. F., ... El-Seedi, H. R. (2019). Marine natural products: A source of novel anticancer drugs. Marine Drugs, 17(9), [491]. https://doi.org/10.3390/md17090491

Marine natural products : A source of novel anticancer drugs. / Khalifa, Shaden A.M.; Elias, Nizar; Farag, Mohamed A.; Chen, Lei; Saeed, Aamer; Hegazy, Mohamed Elamir F.; Moustafa, Moustafa S.; El-Wahed, Aida Abd; Al-Mousawi, Saleh M.; Musharraf, Syed G.; Chang, Fang Rong; Iwasaki, Arihiro; Suenaga, Kiyotake; Alajlani, Muaaz; Göransson, Ulf; El-Seedi, Hesham R.

In: Marine Drugs, Vol. 17, No. 9, 491, 23.08.2019.

Research output: Contribution to journalReview article

Khalifa, SAM, Elias, N, Farag, MA, Chen, L, Saeed, A, Hegazy, MEF, Moustafa, MS, El-Wahed, AA, Al-Mousawi, SM, Musharraf, SG, Chang, FR, Iwasaki, A, Suenaga, K, Alajlani, M, Göransson, U & El-Seedi, HR 2019, 'Marine natural products: A source of novel anticancer drugs', Marine Drugs, vol. 17, no. 9, 491. https://doi.org/10.3390/md17090491
Khalifa SAM, Elias N, Farag MA, Chen L, Saeed A, Hegazy MEF et al. Marine natural products: A source of novel anticancer drugs. Marine Drugs. 2019 Aug 23;17(9). 491. https://doi.org/10.3390/md17090491
Khalifa, Shaden A.M. ; Elias, Nizar ; Farag, Mohamed A. ; Chen, Lei ; Saeed, Aamer ; Hegazy, Mohamed Elamir F. ; Moustafa, Moustafa S. ; El-Wahed, Aida Abd ; Al-Mousawi, Saleh M. ; Musharraf, Syed G. ; Chang, Fang Rong ; Iwasaki, Arihiro ; Suenaga, Kiyotake ; Alajlani, Muaaz ; Göransson, Ulf ; El-Seedi, Hesham R. / Marine natural products : A source of novel anticancer drugs. In: Marine Drugs. 2019 ; Vol. 17, No. 9.
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