Marked improvement with sildenafil in a patient with primary pulmonary hypertension unresponsive to epoprostenol

Masaharu Kataoka, Toru Satoh, Tomohiro Manabe, Toshihisa Anzai, Tsutomu Yoshikawa, Hideo Mitamura, Satoshi Ogawa

Research output: Contribution to journalArticle

7 Citations (Scopus)


We report a 48-year-old woman with right heart failure due to primary pulmonary hypertension. Continuous infusion of epoprostenol (prostaglandin I2) for 1.5 years failed to control her condition, but she was later successfully treated with additional sildenafil for a few months. Her mean pulmonary artery pressure was originally 57 mmHg, increased to 62 mmHg with epoprostenol, and decreased to 45 mmHg with sildenafil. Additional sildenafil may be an effective and life-saving agent in patients with primary pulmonary hypertension who show a poor response to epoprostenol, which is considered to be very powerful medical treatment for the disease.

Original languageEnglish
Pages (from-to)945-950
Number of pages6
JournalInternal Medicine
Issue number10
Publication statusPublished - 2004 Oct 1



  • Epoprostenol
  • Primary pulmonary hypertension
  • Right heart failure
  • Sildenafil

ASJC Scopus subject areas

  • Internal Medicine

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