Marked potentiation of activity of β-lactams against methicillin-resistant Staphylococcus aureus by corilagin

M. Shimizu, S. Shiota, T. Mizushima, H. Ito, T. Hatano, T. Yoshida, T. Tsuchiya

Research output: Contribution to journalArticlepeer-review

94 Citations (Scopus)

Abstract

We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of β-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various β-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.

Original languageEnglish
Pages (from-to)3198-3201
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number11
DOIs
Publication statusPublished - 2001

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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