TY - JOUR
T1 - Marked potentiation of activity of β-lactams against methicillin-resistant Staphylococcus aureus by corilagin
AU - Shimizu, M.
AU - Shiota, S.
AU - Mizushima, T.
AU - Ito, H.
AU - Hatano, T.
AU - Yoshida, T.
AU - Tsuchiya, T.
PY - 2001
Y1 - 2001
N2 - We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of β-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various β-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.
AB - We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of β-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various β-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.
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U2 - 10.1128/AAC.45.11.3198-3201.2001
DO - 10.1128/AAC.45.11.3198-3201.2001
M3 - Article
C2 - 11600378
AN - SCOPUS:0034780297
SN - 0066-4804
VL - 45
SP - 3198
EP - 3201
JO - Antimicrobial Agents and Chemotherapy
JF - Antimicrobial Agents and Chemotherapy
IS - 11
ER -
