Marked potentiation of activity of β-lactams against methicillin-resistant Staphylococcus aureus by corilagin

M. Shimizu, S. Shiota, T. Mizushima, H. Ito, T. Hatano, T. Yoshida, T. Tsuchiya

Research output: Contribution to journalArticle

90 Citations (Scopus)

Abstract

We found that an extract of Arctostaphylos uva-ursi markedly reduced the MICs of β-lactam antibiotics, such as oxacillin and cefmetazole, against methicillin-resistant Staphylococcus aureus. We isolated the effective compound and identified it as corilagin. Corilagin reduced the MICs of various β-lactams by 100- to 2,000-fold but not the MICs of other antimicrobial agents tested. The effect of corilagin and oxacillin was synergistic. Corilagin showed a bactericidal action when added to the growth medium in combination with oxacillin.

Original languageEnglish
Pages (from-to)3198-3201
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume45
Issue number11
DOIs
Publication statusPublished - 2001
Externally publishedYes

Fingerprint

Lactams
Methicillin-Resistant Staphylococcus aureus
Oxacillin
Arctostaphylos
Cefmetazole
Anti-Infective Agents
Anti-Bacterial Agents
corilagin
Growth

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Marked potentiation of activity of β-lactams against methicillin-resistant Staphylococcus aureus by corilagin. / Shimizu, M.; Shiota, S.; Mizushima, T.; Ito, H.; Hatano, T.; Yoshida, T.; Tsuchiya, T.

In: Antimicrobial Agents and Chemotherapy, Vol. 45, No. 11, 2001, p. 3198-3201.

Research output: Contribution to journalArticle

Shimizu, M. ; Shiota, S. ; Mizushima, T. ; Ito, H. ; Hatano, T. ; Yoshida, T. ; Tsuchiya, T. / Marked potentiation of activity of β-lactams against methicillin-resistant Staphylococcus aureus by corilagin. In: Antimicrobial Agents and Chemotherapy. 2001 ; Vol. 45, No. 11. pp. 3198-3201.
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AU - Tsuchiya, T.

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