Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis)

Sumiko Shiota, Masato Shimizu, Tohru Mizushima, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya

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We found that epicatechin gallate, a constituent of an extract of tea leaves (green tea) markedly lowered the minimum inhibitory concentration (MIC) of oxacillin and other β-lactams, but not of other antibacterial agents tested, in strains of methicillin-resistant Staphylococcus aureus. The antibacterial action of epicatechin gallate plus oxacillin was a bactericidal one.

Original languageEnglish
Pages (from-to)1388-1390
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Issue number12
Publication statusPublished - 1999 Dec



  • Epicatechin gallate
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Minimum inhibitory concentration (MIC) reduction
  • β-lactam

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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