Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis)

Sumiko Shiota, Masato Shimizu, Tohru Mizushima, Hideyuki Ito, Tsutomu Hatano, Takashi Yoshida, Tomofusa Tsuchiya

Research output: Contribution to journalArticle

99 Citations (Scopus)

Abstract

We found that epicatechin gallate, a constituent of an extract of tea leaves (green tea) markedly lowered the minimum inhibitory concentration (MIC) of oxacillin and other β-lactams, but not of other antibacterial agents tested, in strains of methicillin-resistant Staphylococcus aureus. The antibacterial action of epicatechin gallate plus oxacillin was a bactericidal one.

Original languageEnglish
Pages (from-to)1388-1390
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume22
Issue number12
Publication statusPublished - 1999 Dec
Externally publishedYes

Fingerprint

Camellia sinensis
Oxacillin
Lactams
Microbial Sensitivity Tests
Tea
Methicillin-Resistant Staphylococcus aureus
Anti-Bacterial Agents
epicatechin gallate

Keywords

  • β-lactam
  • Epicatechin gallate
  • Methicillin-resistant Staphylococcus aureus (MRSA)
  • Minimum inhibitory concentration (MIC) reduction

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). / Shiota, Sumiko; Shimizu, Masato; Mizushima, Tohru; Ito, Hideyuki; Hatano, Tsutomu; Yoshida, Takashi; Tsuchiya, Tomofusa.

In: Biological and Pharmaceutical Bulletin, Vol. 22, No. 12, 12.1999, p. 1388-1390.

Research output: Contribution to journalArticle

Shiota, Sumiko ; Shimizu, Masato ; Mizushima, Tohru ; Ito, Hideyuki ; Hatano, Tsutomu ; Yoshida, Takashi ; Tsuchiya, Tomofusa. / Marked reduction in the minimum inhibitory concentration (MIC) of β- lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). In: Biological and Pharmaceutical Bulletin. 1999 ; Vol. 22, No. 12. pp. 1388-1390.
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