Markers of brain illness may be hidden in your olfactory ability

A Japanese perspective

Yuri Masaoka, Christos Pantelis, Anthony Phillips, Mitsuru Kawamura, Masaru Mimura, Genshin Minegishi, Ikuo Homma

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

There is evidence that impaired human cognitive abilities are reflected by loss of olfactory abilities. Declining olfactory perception may be a biomarker for impairment of cognitive function and of impending neurogenerative disorders. As olfactory perception may differ between culture and ethnic group, we sought to confirm this relationship with Japanese participants. In this study, we examined possible relationships between age and olfactory abilities in healthy Japanese subjects (control subjects) over a wide range of ages and compared this relationship with that observed in three neurodegenerative disorders; patients with Parkinson's disease (PD), Type 1 myotonic dystrophy (DM1) and Alzheimer's disease (AD). In control subjects, both threshold and recognition abilities decreased with age. Ability to detect odors was generally intact in most control subjects, however, we found that the abilities of individuals in the three different patient populations to recognize odors were impaired relative to control subjects. All three types of patients exhibited decreased or impaired odor-recognition compared with age-matched controls. Previous studies showed the causes of olfactory impairments in PD and AD patients were attributable to pathological changes and MRI signal abnormalities in limbic areas, including the amygdala (AMG), entorhinal cortex (ENT), hippocampus (HI), and orbitofrontal cortex (OFC). Another study reported that DM1 patients have bilateral lesions in anterior temporal areas, including the subcortical white matter, AMG, ENT and insula. Our findings underscore the need to pay careful attention to significant decreases of odor identification abilities caused by diverse forms of abnormal brain function, especially in the AMG, ENT and HI.

Original languageEnglish
Pages (from-to)182-185
Number of pages4
JournalNeuroscience Letters
Volume549
DOIs
Publication statusPublished - 2013 Aug 9

Fingerprint

Aptitude
Brain
Entorhinal Cortex
Olfactory Perception
Amygdala
Parkinson Disease
Hippocampus
Alzheimer Disease
Myotonic Dystrophy
Prefrontal Cortex
Ethnic Groups
Neurodegenerative Diseases
Cognition
Healthy Volunteers
Biomarkers
Odorants
Population

Keywords

  • Age trajectories
  • Alzheimer's disease
  • Olfactory detection
  • Olfactory recognition
  • Parkinson's disease
  • Type 1 myotonic dystrophy

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Markers of brain illness may be hidden in your olfactory ability : A Japanese perspective. / Masaoka, Yuri; Pantelis, Christos; Phillips, Anthony; Kawamura, Mitsuru; Mimura, Masaru; Minegishi, Genshin; Homma, Ikuo.

In: Neuroscience Letters, Vol. 549, 09.08.2013, p. 182-185.

Research output: Contribution to journalArticle

Masaoka, Y, Pantelis, C, Phillips, A, Kawamura, M, Mimura, M, Minegishi, G & Homma, I 2013, 'Markers of brain illness may be hidden in your olfactory ability: A Japanese perspective', Neuroscience Letters, vol. 549, pp. 182-185. https://doi.org/10.1016/j.neulet.2013.05.077
Masaoka, Yuri ; Pantelis, Christos ; Phillips, Anthony ; Kawamura, Mitsuru ; Mimura, Masaru ; Minegishi, Genshin ; Homma, Ikuo. / Markers of brain illness may be hidden in your olfactory ability : A Japanese perspective. In: Neuroscience Letters. 2013 ; Vol. 549. pp. 182-185.
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