Abstract
There is evidence that impaired human cognitive abilities are reflected by loss of olfactory abilities. Declining olfactory perception may be a biomarker for impairment of cognitive function and of impending neurogenerative disorders. As olfactory perception may differ between culture and ethnic group, we sought to confirm this relationship with Japanese participants. In this study, we examined possible relationships between age and olfactory abilities in healthy Japanese subjects (control subjects) over a wide range of ages and compared this relationship with that observed in three neurodegenerative disorders; patients with Parkinson's disease (PD), Type 1 myotonic dystrophy (DM1) and Alzheimer's disease (AD). In control subjects, both threshold and recognition abilities decreased with age. Ability to detect odors was generally intact in most control subjects, however, we found that the abilities of individuals in the three different patient populations to recognize odors were impaired relative to control subjects. All three types of patients exhibited decreased or impaired odor-recognition compared with age-matched controls. Previous studies showed the causes of olfactory impairments in PD and AD patients were attributable to pathological changes and MRI signal abnormalities in limbic areas, including the amygdala (AMG), entorhinal cortex (ENT), hippocampus (HI), and orbitofrontal cortex (OFC). Another study reported that DM1 patients have bilateral lesions in anterior temporal areas, including the subcortical white matter, AMG, ENT and insula. Our findings underscore the need to pay careful attention to significant decreases of odor identification abilities caused by diverse forms of abnormal brain function, especially in the AMG, ENT and HI.
| Original language | English |
|---|---|
| Pages (from-to) | 182-185 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 549 |
| DOIs | |
| Publication status | Published - 2013 Aug 9 |
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Keywords
- Age trajectories
- Alzheimer's disease
- Olfactory detection
- Olfactory recognition
- Parkinson's disease
- Type 1 myotonic dystrophy
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Markers of brain illness may be hidden in your olfactory ability : A Japanese perspective. / Masaoka, Yuri; Pantelis, Christos; Phillips, Anthony; Kawamura, Mitsuru; Mimura, Masaru; Minegishi, Genshin; Homma, Ikuo.
In: Neuroscience Letters, Vol. 549, 09.08.2013, p. 182-185.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Markers of brain illness may be hidden in your olfactory ability
T2 - A Japanese perspective
AU - Masaoka, Yuri
AU - Pantelis, Christos
AU - Phillips, Anthony
AU - Kawamura, Mitsuru
AU - Mimura, Masaru
AU - Minegishi, Genshin
AU - Homma, Ikuo
PY - 2013/8/9
Y1 - 2013/8/9
N2 - There is evidence that impaired human cognitive abilities are reflected by loss of olfactory abilities. Declining olfactory perception may be a biomarker for impairment of cognitive function and of impending neurogenerative disorders. As olfactory perception may differ between culture and ethnic group, we sought to confirm this relationship with Japanese participants. In this study, we examined possible relationships between age and olfactory abilities in healthy Japanese subjects (control subjects) over a wide range of ages and compared this relationship with that observed in three neurodegenerative disorders; patients with Parkinson's disease (PD), Type 1 myotonic dystrophy (DM1) and Alzheimer's disease (AD). In control subjects, both threshold and recognition abilities decreased with age. Ability to detect odors was generally intact in most control subjects, however, we found that the abilities of individuals in the three different patient populations to recognize odors were impaired relative to control subjects. All three types of patients exhibited decreased or impaired odor-recognition compared with age-matched controls. Previous studies showed the causes of olfactory impairments in PD and AD patients were attributable to pathological changes and MRI signal abnormalities in limbic areas, including the amygdala (AMG), entorhinal cortex (ENT), hippocampus (HI), and orbitofrontal cortex (OFC). Another study reported that DM1 patients have bilateral lesions in anterior temporal areas, including the subcortical white matter, AMG, ENT and insula. Our findings underscore the need to pay careful attention to significant decreases of odor identification abilities caused by diverse forms of abnormal brain function, especially in the AMG, ENT and HI.
AB - There is evidence that impaired human cognitive abilities are reflected by loss of olfactory abilities. Declining olfactory perception may be a biomarker for impairment of cognitive function and of impending neurogenerative disorders. As olfactory perception may differ between culture and ethnic group, we sought to confirm this relationship with Japanese participants. In this study, we examined possible relationships between age and olfactory abilities in healthy Japanese subjects (control subjects) over a wide range of ages and compared this relationship with that observed in three neurodegenerative disorders; patients with Parkinson's disease (PD), Type 1 myotonic dystrophy (DM1) and Alzheimer's disease (AD). In control subjects, both threshold and recognition abilities decreased with age. Ability to detect odors was generally intact in most control subjects, however, we found that the abilities of individuals in the three different patient populations to recognize odors were impaired relative to control subjects. All three types of patients exhibited decreased or impaired odor-recognition compared with age-matched controls. Previous studies showed the causes of olfactory impairments in PD and AD patients were attributable to pathological changes and MRI signal abnormalities in limbic areas, including the amygdala (AMG), entorhinal cortex (ENT), hippocampus (HI), and orbitofrontal cortex (OFC). Another study reported that DM1 patients have bilateral lesions in anterior temporal areas, including the subcortical white matter, AMG, ENT and insula. Our findings underscore the need to pay careful attention to significant decreases of odor identification abilities caused by diverse forms of abnormal brain function, especially in the AMG, ENT and HI.
KW - Age trajectories
KW - Alzheimer's disease
KW - Olfactory detection
KW - Olfactory recognition
KW - Parkinson's disease
KW - Type 1 myotonic dystrophy
UR - http://www.scopus.com/inward/record.url?scp=84880723651&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880723651&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2013.05.077
DO - 10.1016/j.neulet.2013.05.077
M3 - Article
VL - 549
SP - 182
EP - 185
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -