Martefragin A, a novel indole alkaloid isolated from red alga, inhibits lipid peroxidation

Satoshi Takahashi; Takayuki Matsunaga; Chika Hasegawa; Haruo Saito; Daisuke Fujita; Fumiyuki Kiuchi; Yoshisuke Tsuda

doi:10.1248/cpb.46.1527

Martefragin A, a novel indole alkaloid isolated from red alga, inhibits lipid peroxidation

Satoshi Takahashi, Takayuki Matsunaga, Chika Hasegawa, Haruo Saito, Daisuke Fujita, Fumiyuki Kiuchi, Yoshisuke Tsuda

Research output: Contribution to journal › Article › peer-review

73 Citations (Scopus)

Abstract

Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including ¹H- and ¹³C-NMR, ¹H-¹H correlation spectroscopy (COSY), and ¹³C-¹H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC₅₀ values of 1, α-tocopherol and ascorbic acid were 2.8, 87 and 200 μm, respectively.

Original language	English
Pages (from-to)	1527-1529
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	46
Issue number	10
DOIs	https://doi.org/10.1248/cpb.46.1527
Publication status	Published - 1998
Externally published	Yes

Keywords

Lipid peroxidation
Martefragin A
Martensia fragilis

ASJC Scopus subject areas

Chemistry(all)
Drug Discovery

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10.1248/cpb.46.1527

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abstract = "Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including 1H- and 13C-NMR, 1H-1H correlation spectroscopy (COSY), and 13C-1H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC50 values of 1, α-tocopherol and ascorbic acid were 2.8, 87 and 200 μm, respectively.",

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T1 - Martefragin A, a novel indole alkaloid isolated from red alga, inhibits lipid peroxidation

AU - Takahashi, Satoshi

AU - Matsunaga, Takayuki

AU - Hasegawa, Chika

AU - Saito, Haruo

AU - Fujita, Daisuke

AU - Kiuchi, Fumiyuki

AU - Tsuda, Yoshisuke

PY - 1998

Y1 - 1998

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AB - Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including 1H- and 13C-NMR, 1H-1H correlation spectroscopy (COSY), and 13C-1H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC50 values of 1, α-tocopherol and ascorbic acid were 2.8, 87 and 200 μm, respectively.

KW - Lipid peroxidation

KW - Martefragin A

KW - Martensia fragilis

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Martefragin A, a novel indole alkaloid isolated from red alga, inhibits lipid peroxidation

Abstract

Keywords

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