Martefragin A, a novel indole alkaloid isolated from red alga, inhibits lipid peroxidation

Satoshi Takahashi, Takayuki Matsunaga, Chika Hasegawa, Haruo Saito, Daisuke Fujita, Fumiyuki Kiuchi, Yoshisuke Tsuda

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Martefragin A (1), a novel indole alkaloid, was isolated from a red alga, Martensia fragilis, by repeated column chromatography. The structure of 1 was elucidated on the basis of spectral analysis of its methyl ester (2), including 1H- and 13C-NMR, 1H-1H correlation spectroscopy (COSY), and 13C-1H COSY. A single crystal X-ray analysis of the hydrochloride of 1 confirmed the assignment. Martefragin A (1) showed inhibitory activity on NADPH-dependent lipid peroxidation in rat liver microsomes. The IC50 values of 1, α-tocopherol and ascorbic acid were 2.8, 87 and 200 μm, respectively.

Original languageEnglish
Pages (from-to)1527-1529
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume46
Issue number10
DOIs
Publication statusPublished - 1998 Jan 1
Externally publishedYes

Keywords

  • Lipid peroxidation
  • Martefragin A
  • Martensia fragilis

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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