Mathematical projection model of visual loss due to fuchs corneal dystrophy

Shin Hatou, Shigeto Shimmura, Jun Shimazaki, Tomohiko Usui, Shiro Amano, Hideaki Yokogawa, Akira Kobayashi, Xiaodong Zheng, Atsushi Shiraishi, Yuichi Ohashi, Tsutomu Inatomi, Kazuo Tsubota

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose. To devise a mathematical disease classification model for eyes with primary guttata cornea, on the bases of endothelial loss trajectory and probability of advanced disease. Methods. A series of 1971 patients (3281 eyes), some with and some without guttata corneas, undergoing specular microscopy were retrospectively reviewed. The eyes were classified into four stages; stage 0, without guttae; 1, guttata cornea without edema; 2, mild Fuchs' corneal dystrophy (FCD); and 3, severe FCD, according to clinical records, and patient age and corneal endothelial cell density (ECD) were plotted. Nonparametric density smoothing was used to create a contour map, and a best-fit curve for ECD loss was calculated. The relation between ECD decrease rate and the stages were evaluated. Results. Endothelial decrease rate in stage 0 was 0.44%/year, which was compatible with that of normal eyes reported in previous studies. Decrease rates of stages 1, 2, and 3 were 0.81%, 2.65%, and 3.08%/ year, respectively. The age-ECD loss curves of 1.40%/year (ECO 1.4) and 2.00%/year (ECO 2.0) further divided stage 1 into three subgroups; stage 1a, asymptomatic guttata cornea; 1b, borderline guttata cornea; and 1c, pre-FCD. The ECO 2.0 cutoff line differentiated eyes with FCD from those without edema with a sensitivity and specificity of >90%. Stage 1c eyes were below ECO 2.0 and had a decrease rate as high as FCD. Conclusions. This mathematical model can be used to predict the prognosis of patients with primary guttata cornea.

Original languageEnglish
Pages (from-to)7888-7893
Number of pages6
JournalInvestigative Ophthalmology and Visual Science
Volume52
Issue number11
DOIs
Publication statusPublished - 2011 Oct

Fingerprint

Fuchs' Endothelial Dystrophy
Cornea
Theoretical Models
Endothelial Cells
Cell Count
Edema
Microscopy
Corneal Dystrophy, Fuchs Endothelial, 1
Sensitivity and Specificity

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience
  • Medicine(all)

Cite this

Mathematical projection model of visual loss due to fuchs corneal dystrophy. / Hatou, Shin; Shimmura, Shigeto; Shimazaki, Jun; Usui, Tomohiko; Amano, Shiro; Yokogawa, Hideaki; Kobayashi, Akira; Zheng, Xiaodong; Shiraishi, Atsushi; Ohashi, Yuichi; Inatomi, Tsutomu; Tsubota, Kazuo.

In: Investigative Ophthalmology and Visual Science, Vol. 52, No. 11, 10.2011, p. 7888-7893.

Research output: Contribution to journalArticle

Hatou, S, Shimmura, S, Shimazaki, J, Usui, T, Amano, S, Yokogawa, H, Kobayashi, A, Zheng, X, Shiraishi, A, Ohashi, Y, Inatomi, T & Tsubota, K 2011, 'Mathematical projection model of visual loss due to fuchs corneal dystrophy', Investigative Ophthalmology and Visual Science, vol. 52, no. 11, pp. 7888-7893. https://doi.org/10.1167/iovs.11-8040
Hatou, Shin ; Shimmura, Shigeto ; Shimazaki, Jun ; Usui, Tomohiko ; Amano, Shiro ; Yokogawa, Hideaki ; Kobayashi, Akira ; Zheng, Xiaodong ; Shiraishi, Atsushi ; Ohashi, Yuichi ; Inatomi, Tsutomu ; Tsubota, Kazuo. / Mathematical projection model of visual loss due to fuchs corneal dystrophy. In: Investigative Ophthalmology and Visual Science. 2011 ; Vol. 52, No. 11. pp. 7888-7893.
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abstract = "Purpose. To devise a mathematical disease classification model for eyes with primary guttata cornea, on the bases of endothelial loss trajectory and probability of advanced disease. Methods. A series of 1971 patients (3281 eyes), some with and some without guttata corneas, undergoing specular microscopy were retrospectively reviewed. The eyes were classified into four stages; stage 0, without guttae; 1, guttata cornea without edema; 2, mild Fuchs' corneal dystrophy (FCD); and 3, severe FCD, according to clinical records, and patient age and corneal endothelial cell density (ECD) were plotted. Nonparametric density smoothing was used to create a contour map, and a best-fit curve for ECD loss was calculated. The relation between ECD decrease rate and the stages were evaluated. Results. Endothelial decrease rate in stage 0 was 0.44{\%}/year, which was compatible with that of normal eyes reported in previous studies. Decrease rates of stages 1, 2, and 3 were 0.81{\%}, 2.65{\%}, and 3.08{\%}/ year, respectively. The age-ECD loss curves of 1.40{\%}/year (ECO 1.4) and 2.00{\%}/year (ECO 2.0) further divided stage 1 into three subgroups; stage 1a, asymptomatic guttata cornea; 1b, borderline guttata cornea; and 1c, pre-FCD. The ECO 2.0 cutoff line differentiated eyes with FCD from those without edema with a sensitivity and specificity of >90{\%}. Stage 1c eyes were below ECO 2.0 and had a decrease rate as high as FCD. Conclusions. This mathematical model can be used to predict the prognosis of patients with primary guttata cornea.",
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AU - Hatou, Shin

AU - Shimmura, Shigeto

AU - Shimazaki, Jun

AU - Usui, Tomohiko

AU - Amano, Shiro

AU - Yokogawa, Hideaki

AU - Kobayashi, Akira

AU - Zheng, Xiaodong

AU - Shiraishi, Atsushi

AU - Ohashi, Yuichi

AU - Inatomi, Tsutomu

AU - Tsubota, Kazuo

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