Matrix metalloproteinase gene expression in chronic gastric ulcer: A potential role of eosinophils in perforation

Yoshihide Otani, Yoshihiko Sakurai, Kaori Kameyama, Naoki Igarashi, Takeyoshi Yokoyama, Tetsuro Kubota, Koichiro Kumai, Masaki Kitajima

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Gene expression of matrix degrading enzymes was investigated in surgical specimens of perforated gastric ulcers. In these ulcers, the inflammatory cells infiltrating into the granulation tissue were granulocytes, particularly eosinophils. The extracellular matrix of the stomach wall consists mainly of collagen types I and III, which are selectively degraded by matrix metalloproteinase-1 (MMP-1). MMP-1 mRNA was detected in the cytoplasm of infiltrating cells, suggesting that eosinophils play an important role in ulcer recurrence and in perforation of the stomach wall. The degree of eosinophil infiltration into an ulcer base may be a useful marker for the risk of perforation. Patients showing this marker may benefit from a prophylactic therapy for preventing severe complications. The control of MMP gene expression represents a potential strategy for the treatment of recurrent gastric ulcer.

Original languageEnglish
JournalJournal of Clinical Gastroenterology
Volume25
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 1997

Fingerprint

Stomach Ulcer
Matrix Metalloproteinases
Eosinophils
Ulcer
Matrix Metalloproteinase 1
Gene Expression
Stomach
Collagen Type III
Granulation Tissue
Collagen Type I
Granulocytes
Extracellular Matrix
Cytoplasm
Recurrence
Messenger RNA
Enzymes
Therapeutics

Keywords

  • Collagen
  • Eosinophil
  • Extracellular matrix
  • Gastric ulcer
  • Matrix metalloproteinase
  • Perforation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Matrix metalloproteinase gene expression in chronic gastric ulcer : A potential role of eosinophils in perforation. / Otani, Yoshihide; Sakurai, Yoshihiko; Kameyama, Kaori; Igarashi, Naoki; Yokoyama, Takeyoshi; Kubota, Tetsuro; Kumai, Koichiro; Kitajima, Masaki.

In: Journal of Clinical Gastroenterology, Vol. 25, No. SUPPL. 1, 1997.

Research output: Contribution to journalArticle

Otani, Yoshihide ; Sakurai, Yoshihiko ; Kameyama, Kaori ; Igarashi, Naoki ; Yokoyama, Takeyoshi ; Kubota, Tetsuro ; Kumai, Koichiro ; Kitajima, Masaki. / Matrix metalloproteinase gene expression in chronic gastric ulcer : A potential role of eosinophils in perforation. In: Journal of Clinical Gastroenterology. 1997 ; Vol. 25, No. SUPPL. 1.
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