Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases

Review Article

Takayuki Shiomi, Vincent Lemaître, Jeanine D'Armiento, Yasunori Okada

Research output: Contribution to journalArticle

125 Citations (Scopus)

Abstract

Cellular functions within tissues are strictly regulated by the tissue microenvironment which comprises extracellular matrix and extracellular matrix-deposited factors such as growth factors, cytokines and chemokines. These molecules are metabolized by matrix metalloproteinases (MMP), a disintegrin and metalloproteinases (ADAM) and ADAM with thrombospondin motifs (ADAMTS), which are members of the metzincin superfamily. They function in various pathological conditions of both neoplastic and non-neoplastic diseases by digesting different substrates under the control of tissue inhibitors of metalloproteinases (TIMP) and reversion-inducing, cysteine-rich protein with Kazal motifs (RECK). In neoplastic diseases MMP play a central role in cancer cell invasion and metastases, and ADAM are also important to cancer cell proliferation and progression through the metabolism of growth factors and their receptors. Numerous papers have described the involvement of these metalloproteinases in non-neoplastic diseases in nearly every organ. In contrast to the numerous review articles on their roles in cancer cell proliferation and progression, there are very few articles discussing non-neoplastic diseases. This review therefore will focus on the properties of MMP, ADAM and ADAMTS and their implications for non-neoplastic diseases of the cardiovascular system, respiratory system, central nervous system, digestive system, renal system, wound healing and infection, and joints and muscular system.

Original languageEnglish
Pages (from-to)477-496
Number of pages20
JournalPathology International
Volume60
Issue number7
DOIs
Publication statusPublished - 2010

Fingerprint

Thrombospondins
Disintegrins
Metalloproteases
Matrix Metalloproteinases
Extracellular Matrix
Cell Proliferation
Tissue Inhibitor of Metalloproteinases
Digestive System
Neoplasms
Growth Factor Receptors
Wound Infection
Cardiovascular System
Chemokines
Respiratory System
Wound Healing
Cysteine
Intercellular Signaling Peptides and Proteins
Central Nervous System
Joints
Cytokines

Keywords

  • ADAM
  • ADAMTS
  • Extracellular matrix
  • Matrix metalloproteinase
  • Non-neoplastic diseases
  • Tissue inhibitor of metalloproteinases

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medicine(all)

Cite this

Matrix metalloproteinases, a disintegrin and metalloproteinases, and a disintegrin and metalloproteinases with thrombospondin motifs in non-neoplastic diseases : Review Article. / Shiomi, Takayuki; Lemaître, Vincent; D'Armiento, Jeanine; Okada, Yasunori.

In: Pathology International, Vol. 60, No. 7, 2010, p. 477-496.

Research output: Contribution to journalArticle

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