TY - JOUR
T1 - Mean diffusivity of basal ganglia and thalamus specifically associated with motivational states among mood states
AU - Takeuchi, Hikaru
AU - Taki, Yasuyuki
AU - Sekiguchi, Atsushi
AU - Nouchi, Rui
AU - Kotozaki, Yuka
AU - Nakagawa, Seishu
AU - Miyauchi, Carlos Makoto
AU - Iizuka, Kunio
AU - Yokoyama, Ryoichi
AU - Shinada, Takamitsu
AU - Yamamoto, Yuki
AU - Hanawa, Sugiko
AU - Araki, Tsuyoshi
AU - Kunitoki, Keiko
AU - Sassa, Yuko
AU - Kawashima, Ryuta
N1 - Funding Information:
We respectfully thank Yuki Yamada for operating the MRI scanner, Yuriko Suzuki from Philips for advice on the DWI and Haruka Nouchi for being an examiner of psychological tests. We also thank study participants, the other examiners of psychological tests, and all of our colleagues in Institute of Development, Aging and Cancer and in Tohoku University for their support. This study was supported by a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306) and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology. The authors would like to thank Enago ( http://www.enago.jp ) for the English language review.
Publisher Copyright:
© 2016, Springer-Verlag Berlin Heidelberg.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions. We detected associations between the higher Vigor subscale of POMS and lower MD in the right globus pallidum, right putamen to right posterior insula, right caudate body, and right thalamus, and these associations were highly specific to the Vigor subscale. Similarly, the association of the motivational state with creativity measured by divergent thinking (CMDT) was rather specific and prominent compared with that of the other mood states and cognitive functions. In conclusion, when affective states are finely divided, only the motivational state is associated with MD in the areas related to the dopaminergic system, and psychological mechanisms that had been associated with dopaminergic system (CMDT). These results suggest that these mechanisms specifically contribute to the motivational state and not to the other states, such as depression and anxiety.
AB - Previously, we proposed that the mean diffusivity (MD), a measure of diffusion tensor imaging (DTI) in areas of the dopaminergic system (MDDS), is associated with motivation. In this study, we tested if and how the motivational state is associated with MD in comparison with other mood states. We also tested the associations of these mood states with multiple cognitive functions. We examined these issues in 766 right-handed healthy young adults. We employed analyses of MD and a psychological measure of the profile of mood states (POMS) as well as multiple cognitive functions. We detected associations between the higher Vigor subscale of POMS and lower MD in the right globus pallidum, right putamen to right posterior insula, right caudate body, and right thalamus, and these associations were highly specific to the Vigor subscale. Similarly, the association of the motivational state with creativity measured by divergent thinking (CMDT) was rather specific and prominent compared with that of the other mood states and cognitive functions. In conclusion, when affective states are finely divided, only the motivational state is associated with MD in the areas related to the dopaminergic system, and psychological mechanisms that had been associated with dopaminergic system (CMDT). These results suggest that these mechanisms specifically contribute to the motivational state and not to the other states, such as depression and anxiety.
KW - Brain structure
KW - Dopaminergic system
KW - Mean diffusivity
KW - Mood state
KW - Motivation
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U2 - 10.1007/s00429-016-1262-5
DO - 10.1007/s00429-016-1262-5
M3 - Article
C2 - 27364694
AN - SCOPUS:84976463111
SN - 1863-2653
VL - 222
SP - 1027
EP - 1037
JO - Brain Structure and Function
JF - Brain Structure and Function
IS - 2
ER -