TY - JOUR
T1 - Mean diffusivity related to rule-breaking guilt
T2 - the Macbeth effect in the sensorimotor regions
AU - Nakagawa, Seishu
AU - Takeuchi, Hikaru
AU - Taki, Yasuyuki
AU - Nouchi, Rui
AU - Kotozaki, Yuka
AU - Shinada, Takamitsu
AU - Maruyama, Tsukasa
AU - Sekiguchi, Atsushi
AU - Iizuka, Kunio
AU - Yokoyama, Ryoichi
AU - Yamamoto, Yuki
AU - Hanawa, Sugiko
AU - Araki, Tsuyoshi
AU - Makoto Miyauchi, Carlos
AU - Magistro, Daniele
AU - Sakaki, Kohei
AU - Jeong, Hyeonjeong
AU - Sasaki, Yukako
AU - Kawashima, Ryuta
N1 - Funding Information:
We respectfully thank Yuki Yamada for operating the MRI scanner and Haruka Nouchi for administering the psychological tests. Furthermore, we would like to thank the participants in the study, the other individuals who administered psychological tests, and our colleagues in the Institute of Development, Ageing and Cancer at Tohoku University for their support. Dr. H.T. was supported by JST/RISTEX, JST/CREST, a Grant-in-Aid for Young Scientists (B) (KAKENHI 23700306), and a Grant-in-Aid for Young Scientists (A) (KAKENHI 25700012) from the Ministry of Education, Culture, Sports, Science, and Technology, and Health Science Center Foundation. Dr. S.N. was financially supported by the Division of Psychiatry, Tohoku Medical and Pharmaceutical University. We would like to thank Editage (www.editage.jp) for English language editing.
Publisher Copyright:
© 2019, The Author(s).
PY - 2019/12/1
Y1 - 2019/12/1
N2 - Guilt, a self-conscious emotion, includes self-focused role taking and also correlates with other-oriented role-taking. Excess guilt proneness might be relevant to obsessive compulsive disorders. The white matter (WM) neural correlates of the degree of guilt have not yet been determined. We hypothesized that the WM structures involved in feelings of guilt are associated with social and moral cognition (inferior parietal lobule [IPL], prefrontal cortex [PFC], and cingulate), and aimed to visualize this using diffusion MRI. We investigated the association between regional WM structures (WM volume, and fractional anisotropy, and mean diffusivity [MD]), and feelings of guilt in 1196 healthy, young students using MRI and the Guilty Feeling Scale, which comprises interpersonal situation (IPS; guilt from hurting friends) and rule-breaking situation (RBS; deontological guilt) scores. The primary novel finding presented here is that MD in the right somatosensory and motor cortices from arm to hand were positively correlated with RBS scores. Further, consistent with our hypothesis, RBS scores were positively correlated with MD in the same regions. These results would be predicted by the Macbeth effect, an obsession with dirt leading to hand-washing rituals resulting from guilt, made famous by the Shakespearian character Lady Macbeth. “What, will these hands ne’er be clean?” William Shakespeare (Shakespeare, 1606) Macbeth.
AB - Guilt, a self-conscious emotion, includes self-focused role taking and also correlates with other-oriented role-taking. Excess guilt proneness might be relevant to obsessive compulsive disorders. The white matter (WM) neural correlates of the degree of guilt have not yet been determined. We hypothesized that the WM structures involved in feelings of guilt are associated with social and moral cognition (inferior parietal lobule [IPL], prefrontal cortex [PFC], and cingulate), and aimed to visualize this using diffusion MRI. We investigated the association between regional WM structures (WM volume, and fractional anisotropy, and mean diffusivity [MD]), and feelings of guilt in 1196 healthy, young students using MRI and the Guilty Feeling Scale, which comprises interpersonal situation (IPS; guilt from hurting friends) and rule-breaking situation (RBS; deontological guilt) scores. The primary novel finding presented here is that MD in the right somatosensory and motor cortices from arm to hand were positively correlated with RBS scores. Further, consistent with our hypothesis, RBS scores were positively correlated with MD in the same regions. These results would be predicted by the Macbeth effect, an obsession with dirt leading to hand-washing rituals resulting from guilt, made famous by the Shakespearian character Lady Macbeth. “What, will these hands ne’er be clean?” William Shakespeare (Shakespeare, 1606) Macbeth.
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U2 - 10.1038/s41598-019-48654-8
DO - 10.1038/s41598-019-48654-8
M3 - Article
C2 - 31439852
AN - SCOPUS:85071175809
SN - 2045-2322
VL - 9
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 12227
ER -