Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis

Hiroshi Ishiguro; Takanori Kai; Kuniyasu Ogawa

Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis

Hiroshi Ishiguro, Takanori Kai, Kuniyasu Ogawa

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Transient one-dimensional distribution of cryoprotectant concentration in pseudobiological tissues (agar) was measured noninvasively using magnetic resonance imaging (MRI). Cryoprotectants were dimethyl sulfoxide (DMSO) and glycerol, common cryoprotectants penetrating cells. Attenuation of MRI image intensity due to volumetric fraction of solution and relaxation times was also investigated. Apparent diffusivity of each cryoprotectant as a function of agar concentration was determined from the inverse problem analysis. The diffusivity decreased with an increase in agar concentration. This method was also applied to the liver tissues of chicken.

Original language	English
Title of host publication	Advances in Heat and Mass Transfer in Biotechnology
Publisher	American Society of Mechanical Engineers (ASME)
Pages	23-27
Number of pages	5
ISBN (Print)	0791836398, 9780791836392
Publication status	Published - 2002 Jan 1

Publication series

Name	ASME International Mechanical Engineering Congress and Exposition, Proceedings

ASJC Scopus subject areas

Mechanical Engineering

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Ishiguro, H., Kai, T., & Ogawa, K. (2002). Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis. In Advances in Heat and Mass Transfer in Biotechnology (pp. 23-27). (ASME International Mechanical Engineering Congress and Exposition, Proceedings). American Society of Mechanical Engineers (ASME).

Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis. / Ishiguro, Hiroshi; Kai, Takanori; Ogawa, Kuniyasu.

Advances in Heat and Mass Transfer in Biotechnology. American Society of Mechanical Engineers (ASME), 2002. p. 23-27 (ASME International Mechanical Engineering Congress and Exposition, Proceedings).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Ishiguro, H, Kai, T & Ogawa, K 2002, Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis. in Advances in Heat and Mass Transfer in Biotechnology. ASME International Mechanical Engineering Congress and Exposition, Proceedings, American Society of Mechanical Engineers (ASME), pp. 23-27.

Ishiguro H, Kai T, Ogawa K. Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis. In Advances in Heat and Mass Transfer in Biotechnology. American Society of Mechanical Engineers (ASME). 2002. p. 23-27. (ASME International Mechanical Engineering Congress and Exposition, Proceedings).

Ishiguro, Hiroshi ; Kai, Takanori ; Ogawa, Kuniyasu. / Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis. Advances in Heat and Mass Transfer in Biotechnology. American Society of Mechanical Engineers (ASME), 2002. pp. 23-27 (ASME International Mechanical Engineering Congress and Exposition, Proceedings).

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