Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis

Hiroshi Ishiguro, Takanori Kai, Kuniyasu Ogawa

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Transient one-dimensional distribution of cryoprotectant concentration in pseudobiological tissues (agar) was measured noninvasively using magnetic resonance imaging (MRI). Cryoprotectants were dimethyl sulfoxide (DMSO) and glycerol, common cryoprotectants penetrating cells. Attenuation of MRI image intensity due to volumetric fraction of solution and relaxation times was also investigated. Apparent diffusivity of each cryoprotectant as a function of agar concentration was determined from the inverse problem analysis. The diffusivity decreased with an increase in agar concentration. This method was also applied to the liver tissues of chicken.

Original languageEnglish
Title of host publicationASME International Mechanical Engineering Congress and Exposition, Proceedings
PublisherAmerican Society of Mechanical Engineers (ASME)
Pages23-27
Number of pages5
ISBN (Print)0791836398, 9780791836392
Publication statusPublished - 2002

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ASJC Scopus subject areas

  • Mechanical Engineering

Cite this

Ishiguro, H., Kai, T., & Ogawa, K. (2002). Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis. In ASME International Mechanical Engineering Congress and Exposition, Proceedings (pp. 23-27). American Society of Mechanical Engineers (ASME).