TY - GEN
T1 - Measurement of cryoprotectant concentration using MRI in pseudobiological tissues and determination of diffsivity based on inverse problem analysis
AU - Ishiguro, Hiroshi
AU - Kai, Takanori
AU - Ogawa, Kuniyasu
PY - 2002/1/1
Y1 - 2002/1/1
N2 - Transient one-dimensional distribution of cryoprotectant concentration in pseudobiological tissues (agar) was measured noninvasively using magnetic resonance imaging (MRI). Cryoprotectants were dimethyl sulfoxide (DMSO) and glycerol, common cryoprotectants penetrating cells. Attenuation of MRI image intensity due to volumetric fraction of solution and relaxation times was also investigated. Apparent diffusivity of each cryoprotectant as a function of agar concentration was determined from the inverse problem analysis. The diffusivity decreased with an increase in agar concentration. This method was also applied to the liver tissues of chicken.
AB - Transient one-dimensional distribution of cryoprotectant concentration in pseudobiological tissues (agar) was measured noninvasively using magnetic resonance imaging (MRI). Cryoprotectants were dimethyl sulfoxide (DMSO) and glycerol, common cryoprotectants penetrating cells. Attenuation of MRI image intensity due to volumetric fraction of solution and relaxation times was also investigated. Apparent diffusivity of each cryoprotectant as a function of agar concentration was determined from the inverse problem analysis. The diffusivity decreased with an increase in agar concentration. This method was also applied to the liver tissues of chicken.
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M3 - Conference contribution
AN - SCOPUS:78249232045
SN - 0791836398
SN - 9780791836392
T3 - ASME International Mechanical Engineering Congress and Exposition, Proceedings
SP - 23
EP - 27
BT - Advances in Heat and Mass Transfer in Biotechnology
PB - American Society of Mechanical Engineers (ASME)
ER -