Measurement of the perfusion fraction in brain tumors with intravoxel incoherent motion MR imaging

Validation with histopathological vascular density in meningiomas

Osamu Togao, Akio Hiwatashi, Koji Yamashita, Kazufumi Kikuchi, Daichi Momosaka, Koji Yoshimoto, Daisuke Kuga, Masahiro Mizoguchi, Satoshi O. Suzuki, Toru Iwaki, Marc Van Cauteren, Koji Iihara, Hiroshi Honda

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objective: To evaluate the quantification performance of the perfusion fraction (f) measured with intravoxel incoherent motion (IVIM) MR imaging in a comparison with the histological vascular density in meningiomas. Methods: 29 consecutive patients with meningioma (59.0 ± 16.8 years old, 8 males and 21 females) who underwent a subsequent surgical resection were examined with both IVIM imaging and a histopathological analysis. IVIM imaging was conducted using a singleshot SE-EPI sequence with 13 b-factors (0, 10, 20, 30, 50, 80, 100, 200, 300, 400, 600, 800, 1000 s mm-2) at 3T. The perfusion fraction (f) was calculated by fitting the IVIM bi-exponential model. The 90-percentile f-value in the tumor region-of-interest (ROI) was defined as the maximum f-value (f-max). Histopathological vascular density (%Vessel) was measured on CD31-immunostainted histopathological specimens. The correlation and agreement between the f-values and %Vessel was assessed. Results: The f-max (15.5 ± 5.5%) showed excellent agreement [intraclass correlation coefficient (ICC) = 0.754] and a significant correlation (r = 0.69, p < 0.0001) with the %Vessel (12.9 ± 9.4%) of the tumors. The Bland- Altman plot analysis showed excellent agreement between the f-max and %Vessel (bias, -2.6%; 95% limits of agreement, from -16.0 to 10.8%). The f-max was not significantly different among the histological subtypes of meningioma. Conclusion: An excellent agreement and a significant correlation were observed between the f-values and %Vessel. The f-value can be used as a noninvasive quantitative imaging measure to directly assess the vascular volume fraction in brain tumors. Advances in knowledge: The f-value measured by IVIM imaging showed a significant correlation and an excellent agreement with the histological vascular density in the meningiomas. The f-value can be used as a noninvasive and quantitative imaging measure to directly assess the volume fraction of capillaries in brain tumors.

Original languageEnglish
Article number20170912
JournalBritish Journal of Radiology
Volume91
Issue number1085
DOIs
Publication statusPublished - 2018 Jan 1
Externally publishedYes

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Meningioma
Brain Neoplasms
Blood Vessels
Perfusion
Neoplasms

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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Measurement of the perfusion fraction in brain tumors with intravoxel incoherent motion MR imaging : Validation with histopathological vascular density in meningiomas. / Togao, Osamu; Hiwatashi, Akio; Yamashita, Koji; Kikuchi, Kazufumi; Momosaka, Daichi; Yoshimoto, Koji; Kuga, Daisuke; Mizoguchi, Masahiro; Suzuki, Satoshi O.; Iwaki, Toru; Van Cauteren, Marc; Iihara, Koji; Honda, Hiroshi.

In: British Journal of Radiology, Vol. 91, No. 1085, 20170912, 01.01.2018.

Research output: Contribution to journalArticle

Togao, O, Hiwatashi, A, Yamashita, K, Kikuchi, K, Momosaka, D, Yoshimoto, K, Kuga, D, Mizoguchi, M, Suzuki, SO, Iwaki, T, Van Cauteren, M, Iihara, K & Honda, H 2018, 'Measurement of the perfusion fraction in brain tumors with intravoxel incoherent motion MR imaging: Validation with histopathological vascular density in meningiomas', British Journal of Radiology, vol. 91, no. 1085, 20170912. https://doi.org/10.1259/bjr.20170912
Togao, Osamu ; Hiwatashi, Akio ; Yamashita, Koji ; Kikuchi, Kazufumi ; Momosaka, Daichi ; Yoshimoto, Koji ; Kuga, Daisuke ; Mizoguchi, Masahiro ; Suzuki, Satoshi O. ; Iwaki, Toru ; Van Cauteren, Marc ; Iihara, Koji ; Honda, Hiroshi. / Measurement of the perfusion fraction in brain tumors with intravoxel incoherent motion MR imaging : Validation with histopathological vascular density in meningiomas. In: British Journal of Radiology. 2018 ; Vol. 91, No. 1085.
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abstract = "Objective: To evaluate the quantification performance of the perfusion fraction (f) measured with intravoxel incoherent motion (IVIM) MR imaging in a comparison with the histological vascular density in meningiomas. Methods: 29 consecutive patients with meningioma (59.0 ± 16.8 years old, 8 males and 21 females) who underwent a subsequent surgical resection were examined with both IVIM imaging and a histopathological analysis. IVIM imaging was conducted using a singleshot SE-EPI sequence with 13 b-factors (0, 10, 20, 30, 50, 80, 100, 200, 300, 400, 600, 800, 1000 s mm-2) at 3T. The perfusion fraction (f) was calculated by fitting the IVIM bi-exponential model. The 90-percentile f-value in the tumor region-of-interest (ROI) was defined as the maximum f-value (f-max). Histopathological vascular density ({\%}Vessel) was measured on CD31-immunostainted histopathological specimens. The correlation and agreement between the f-values and {\%}Vessel was assessed. Results: The f-max (15.5 ± 5.5{\%}) showed excellent agreement [intraclass correlation coefficient (ICC) = 0.754] and a significant correlation (r = 0.69, p < 0.0001) with the {\%}Vessel (12.9 ± 9.4{\%}) of the tumors. The Bland- Altman plot analysis showed excellent agreement between the f-max and {\%}Vessel (bias, -2.6{\%}; 95{\%} limits of agreement, from -16.0 to 10.8{\%}). The f-max was not significantly different among the histological subtypes of meningioma. Conclusion: An excellent agreement and a significant correlation were observed between the f-values and {\%}Vessel. The f-value can be used as a noninvasive quantitative imaging measure to directly assess the vascular volume fraction in brain tumors. Advances in knowledge: The f-value measured by IVIM imaging showed a significant correlation and an excellent agreement with the histological vascular density in the meningiomas. The f-value can be used as a noninvasive and quantitative imaging measure to directly assess the volume fraction of capillaries in brain tumors.",
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AU - Hiwatashi, Akio

AU - Yamashita, Koji

AU - Kikuchi, Kazufumi

AU - Momosaka, Daichi

AU - Yoshimoto, Koji

AU - Kuga, Daisuke

AU - Mizoguchi, Masahiro

AU - Suzuki, Satoshi O.

AU - Iwaki, Toru

AU - Van Cauteren, Marc

AU - Iihara, Koji

AU - Honda, Hiroshi

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N2 - Objective: To evaluate the quantification performance of the perfusion fraction (f) measured with intravoxel incoherent motion (IVIM) MR imaging in a comparison with the histological vascular density in meningiomas. Methods: 29 consecutive patients with meningioma (59.0 ± 16.8 years old, 8 males and 21 females) who underwent a subsequent surgical resection were examined with both IVIM imaging and a histopathological analysis. IVIM imaging was conducted using a singleshot SE-EPI sequence with 13 b-factors (0, 10, 20, 30, 50, 80, 100, 200, 300, 400, 600, 800, 1000 s mm-2) at 3T. The perfusion fraction (f) was calculated by fitting the IVIM bi-exponential model. The 90-percentile f-value in the tumor region-of-interest (ROI) was defined as the maximum f-value (f-max). Histopathological vascular density (%Vessel) was measured on CD31-immunostainted histopathological specimens. The correlation and agreement between the f-values and %Vessel was assessed. Results: The f-max (15.5 ± 5.5%) showed excellent agreement [intraclass correlation coefficient (ICC) = 0.754] and a significant correlation (r = 0.69, p < 0.0001) with the %Vessel (12.9 ± 9.4%) of the tumors. The Bland- Altman plot analysis showed excellent agreement between the f-max and %Vessel (bias, -2.6%; 95% limits of agreement, from -16.0 to 10.8%). The f-max was not significantly different among the histological subtypes of meningioma. Conclusion: An excellent agreement and a significant correlation were observed between the f-values and %Vessel. The f-value can be used as a noninvasive quantitative imaging measure to directly assess the vascular volume fraction in brain tumors. Advances in knowledge: The f-value measured by IVIM imaging showed a significant correlation and an excellent agreement with the histological vascular density in the meningiomas. The f-value can be used as a noninvasive and quantitative imaging measure to directly assess the volume fraction of capillaries in brain tumors.

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