Mechanical property of in vitro regenerated cartilage

Shogo Miyata, Takashi Ushida, Guoping Chen, Yasuo Nitta, Tetsuya Tateishi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Damaged articular cartilage has a very limited capability of self-healing. The need for improved treatment of cartilage defects, which involve over 1 percent of population in Japan, has motivated research to create regenerated cartilage. Regenerated cartilage is engineered by culturing autologous chondrocytes on biodegradable scaffolds. We studied changes in biomechanical property, especially dynamic visco-elasticity during 6 weeks of in vitro culture. The results suggest that the ability of water holding was increased by new extracellular matrix (ECM) synthesis during 4 weeks of in vitro culture, although the ability of solid matrix (ECM and scaffold) to resist compression elastically was reduced.

Original languageEnglish
Pages (from-to)90-94
Number of pages5
JournalNippon Kikai Gakkai Ronbunshu, A Hen/Transactions of the Japan Society of Mechanical Engineers, Part A
Volume69
Issue number1
Publication statusPublished - 2003 Jan 1
Externally publishedYes

Keywords

  • Biomaterials
  • Mechanical property
  • Medical engineering
  • Regenerated cartilage
  • Visco elasticity

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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