Mechanism and biological significance of sequential cleavages of CD44 - A potential molecular target for cancer therapy

Osamu Nagano; Daizo Murakami; Hideyuki Saya

Mechanism and biological significance of sequential cleavages of CD44 - A potential molecular target for cancer therapy

Osamu Nagano, Daizo Murakami, Hideyuki Saya

Research output: Contribution to journal › Article › peer-review

Abstract

CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and is implicated in diverse biological processes. Recently, CD44 has been shown to undergo sequential proteolytic cleavages in its ectodomain and intramembranous domain. These cleavages are emerging as key regulatory events for the CD44-dependent cell-matrix interaction and signaling pathway and can be therapeutic targets for cancer invasion.

Original language	English
Pages (from-to)	405-411
Number of pages	7
Journal	Biotherapy
Volume	18
Issue number	5
Publication status	Published - 2004 Sept 1
Externally published	Yes

Keywords

Adhesion molecule
CD44
Cancer metastasis
Sequential cleavage
Signal transduction

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and is implicated in diverse biological processes. Recently, CD44 has been shown to undergo sequential proteolytic cleavages in its ectodomain and intramembranous domain. These cleavages are emerging as key regulatory events for the CD44-dependent cell-matrix interaction and signaling pathway and can be therapeutic targets for cancer invasion.",

keywords = "Adhesion molecule, CD44, Cancer metastasis, Sequential cleavage, Signal transduction",

author = "Osamu Nagano and Daizo Murakami and Hideyuki Saya",

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AU - Nagano, Osamu

AU - Murakami, Daizo

AU - Saya, Hideyuki

PY - 2004/9/1

Y1 - 2004/9/1

N2 - CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and is implicated in diverse biological processes. Recently, CD44 has been shown to undergo sequential proteolytic cleavages in its ectodomain and intramembranous domain. These cleavages are emerging as key regulatory events for the CD44-dependent cell-matrix interaction and signaling pathway and can be therapeutic targets for cancer invasion.

AB - CD44 is an adhesion molecule that interacts with hyaluronic acid (HA) and is implicated in diverse biological processes. Recently, CD44 has been shown to undergo sequential proteolytic cleavages in its ectodomain and intramembranous domain. These cleavages are emerging as key regulatory events for the CD44-dependent cell-matrix interaction and signaling pathway and can be therapeutic targets for cancer invasion.

KW - Adhesion molecule

KW - CD44

KW - Cancer metastasis

KW - Sequential cleavage

KW - Signal transduction

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M3 - Article

AN - SCOPUS:6944248718

SN - 0914-2223

VL - 18

SP - 405

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JO - Biotherapy

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ER -

Mechanism and biological significance of sequential cleavages of CD44 - A potential molecular target for cancer therapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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