Mechanism of action of a new macromolecular antitumor antibiotic, C-1027

Yoshikazu Sugimoto, Toshio Otani, Shinji Ole, Konstanty Wierzba, Yuji Yamada

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

C-1027 is a new antitumor protein antibiotic containing a non-protein chromophore. The active moiety and the mechanism of action of this antibiotic were studied. C-1027 and its chromophore inhibited the growth of KB carcinoma and LI 210 leukemia cells, even at extremely low concentrations. C-1027 inhibited DNA synthesis of L1210 cells and cleaved cellular DNA in a drug concentrationdependent manner. C-1027 and chromophore caused directly DNA single strand breaks in the purified DNA without any supplement of reducing agents. These results suggest that C-1027 chromophore may inhibit cell growth by causing DNA breakage with subsequent inhibition of DNA synthesis.

Original languageEnglish
Pages (from-to)417-421
Number of pages5
JournalThe Journal of Antibiotics
Volume43
Issue number4
DOIs
Publication statusPublished - 1990 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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