Mechanism of action of a new macromolecular antitumor antibiotic, C-1027

Yoshikazu Sugimoto; Toshio Otani; Shinji Ole; Konstanty Wierzba; Yuji Yamada

doi:10.7164/antibiotics.43.417

Mechanism of action of a new macromolecular antitumor antibiotic, C-1027

Yoshikazu Sugimoto, Toshio Otani, Shinji Ole, Konstanty Wierzba, Yuji Yamada

Research output: Contribution to journal › Article › peer-review

89 Citations (Scopus)

Abstract

C-1027 is a new antitumor protein antibiotic containing a non-protein chromophore. The active moiety and the mechanism of action of this antibiotic were studied. C-1027 and its chromophore inhibited the growth of KB carcinoma and LI 210 leukemia cells, even at extremely low concentrations. C-1027 inhibited DNA synthesis of L1210 cells and cleaved cellular DNA in a drug concentrationdependent manner. C-1027 and chromophore caused directly DNA single strand breaks in the purified DNA without any supplement of reducing agents. These results suggest that C-1027 chromophore may inhibit cell growth by causing DNA breakage with subsequent inhibition of DNA synthesis.

Original language	English
Pages (from-to)	417-421
Number of pages	5
Journal	The Journal of Antibiotics
Volume	43
Issue number	4
DOIs	https://doi.org/10.7164/antibiotics.43.417
Publication status	Published - 1990
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Drug Discovery

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abstract = "C-1027 is a new antitumor protein antibiotic containing a non-protein chromophore. The active moiety and the mechanism of action of this antibiotic were studied. C-1027 and its chromophore inhibited the growth of KB carcinoma and LI 210 leukemia cells, even at extremely low concentrations. C-1027 inhibited DNA synthesis of L1210 cells and cleaved cellular DNA in a drug concentrationdependent manner. C-1027 and chromophore caused directly DNA single strand breaks in the purified DNA without any supplement of reducing agents. These results suggest that C-1027 chromophore may inhibit cell growth by causing DNA breakage with subsequent inhibition of DNA synthesis.",

author = "Yoshikazu Sugimoto and Toshio Otani and Shinji Ole and Konstanty Wierzba and Yuji Yamada",

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AU - Otani, Toshio

AU - Ole, Shinji

AU - Wierzba, Konstanty

AU - Yamada, Yuji

PY - 1990

Y1 - 1990

N2 - C-1027 is a new antitumor protein antibiotic containing a non-protein chromophore. The active moiety and the mechanism of action of this antibiotic were studied. C-1027 and its chromophore inhibited the growth of KB carcinoma and LI 210 leukemia cells, even at extremely low concentrations. C-1027 inhibited DNA synthesis of L1210 cells and cleaved cellular DNA in a drug concentrationdependent manner. C-1027 and chromophore caused directly DNA single strand breaks in the purified DNA without any supplement of reducing agents. These results suggest that C-1027 chromophore may inhibit cell growth by causing DNA breakage with subsequent inhibition of DNA synthesis.

AB - C-1027 is a new antitumor protein antibiotic containing a non-protein chromophore. The active moiety and the mechanism of action of this antibiotic were studied. C-1027 and its chromophore inhibited the growth of KB carcinoma and LI 210 leukemia cells, even at extremely low concentrations. C-1027 inhibited DNA synthesis of L1210 cells and cleaved cellular DNA in a drug concentrationdependent manner. C-1027 and chromophore caused directly DNA single strand breaks in the purified DNA without any supplement of reducing agents. These results suggest that C-1027 chromophore may inhibit cell growth by causing DNA breakage with subsequent inhibition of DNA synthesis.

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Mechanism of action of a new macromolecular antitumor antibiotic, C-1027

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