Mechanism of age-related changes in renin and adrenocortical steroids

T. Saruta, A. Suzuki, M. Hayashi, T. Yasui, T. Eguchi, E. Kato

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Age-related changes in plasma renin activity (PRA) and in plasma levels of adrenocortical steroids were studied in 140 normotensive men and 128 normotensive women. All were free of disease, and their ages ranged from 20 to 86 years. PRA decreased gradually with age in both men and women, and was slightly lower in women than in men. In the older subjects, the responses of PRA to the administration of furosemide or to dietary sodium restriction plus the upright position for blood sampling were significantly less than in the younger subjects. Apparently the suppression of PRA with age is due either to dysfunction of the juxtaglomerular cells induced by aging, or to reduction in the number of functioning nephrons. The plasma level of aldosterone was also reduced with age, but the levels of deoxycorticosterone, corticosterone, and cortisol were not significantly affected. The suppression of aldosterone seemed to be chiefly dependent upon the suppression of renin activity. However, the possibility remains that disturbed function of the glomerular cells with aging also is related to the suppression of aldosterone, since the response of aldosterone to dietary sodium restriction (upright position for blood sampling), to angiotensin II, and the potassium were greatly reduced.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalJournal of the American Geriatrics Society
Volume28
Issue number5
Publication statusPublished - 1980

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Renin
Steroids
Aldosterone
Dietary Sodium
Cell Aging
Desoxycorticosterone
Nephrons
Furosemide
Corticosterone
Angiotensin II
Hydrocortisone
Potassium

ASJC Scopus subject areas

  • Geriatrics and Gerontology

Cite this

Saruta, T., Suzuki, A., Hayashi, M., Yasui, T., Eguchi, T., & Kato, E. (1980). Mechanism of age-related changes in renin and adrenocortical steroids. Journal of the American Geriatrics Society, 28(5), 210-214.

Mechanism of age-related changes in renin and adrenocortical steroids. / Saruta, T.; Suzuki, A.; Hayashi, M.; Yasui, T.; Eguchi, T.; Kato, E.

In: Journal of the American Geriatrics Society, Vol. 28, No. 5, 1980, p. 210-214.

Research output: Contribution to journalArticle

Saruta, T, Suzuki, A, Hayashi, M, Yasui, T, Eguchi, T & Kato, E 1980, 'Mechanism of age-related changes in renin and adrenocortical steroids', Journal of the American Geriatrics Society, vol. 28, no. 5, pp. 210-214.
Saruta T, Suzuki A, Hayashi M, Yasui T, Eguchi T, Kato E. Mechanism of age-related changes in renin and adrenocortical steroids. Journal of the American Geriatrics Society. 1980;28(5):210-214.
Saruta, T. ; Suzuki, A. ; Hayashi, M. ; Yasui, T. ; Eguchi, T. ; Kato, E. / Mechanism of age-related changes in renin and adrenocortical steroids. In: Journal of the American Geriatrics Society. 1980 ; Vol. 28, No. 5. pp. 210-214.
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