Mechanism of the Central Effects of Dopamine and Metoclopramide on Aldosterone Regulation in the Rat

Kazuoki Kondo, Hiroshi Kawabe, Matsuhiko Hayashi, Masaki Fujimaki, Shusaku Nagahama, Takao Saruta

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

To investigate the mechanism of the central action of dopamine and its antagonist, metoclopramide, on the regulation of aldosterone, studies were performed in 54 conscious rats with and without bilateral nephrectomy. In normal and sham-operated rats, intracerebroventricular injection of dopamine resulted in a significant suppression of plasma renin activity and plasma aldosterone at 30 min, and intracerebroventricular injection of metoclopramide resulted in a significant elevation of plasma renin activity and plasma aldosterone at 30 min without altering the plasma corticosterone and potassium levels. In bilaterally nephrectomized rats, the plasma renin activity was significantly reduced and it did not respond to dopamine or metoclopramide. In these rats, intracerebroventricular injection of metoclopramide exerted no effect on the plasma aldosterone, but intracerebroventricular injection of dopamine increased the plasma aldosterone slightly. However, this increase was not statistically significant. These findings suggest that the dopaminergic system in the brain is involved in the regulation of aldosterone secretion, mainly with changes in the peripheral renin-angiotensin axis in rats.

Original languageEnglish
Pages (from-to)543-549
Number of pages7
JournalEndocrinologia Japonica
Volume30
Issue number4
DOIs
Publication statusPublished - 1983 Jan

ASJC Scopus subject areas

  • Endocrinology
  • Engineering(all)

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