Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

Volker Spindler, Rüdiger Eming, Enno Schmidt, Masayuki Amagai, Sergei Grando, Marcel F. Jonkman, Andrew P. Kowalczyk, Eliane J. Müller, Aimee S. Payne, Carlo Pincelli, Animesh A. Sinha, Eli Sprecher, Detlef Zillikens, Michael Hertl, Jens Waschke

Research output: Contribution to journalReview article

33 Citations (Scopus)

Abstract

The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalJournal of Investigative Dermatology
Volume138
Issue number1
DOIs
Publication statusPublished - 2018 Jan

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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