Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

Volker Spindler, Rüdiger Eming, Enno Schmidt, Masayuki Amagai, Sergei Grando, Marcel F. Jonkman, Andrew P. Kowalczyk, Eliane J. Müller, Aimee S. Payne, Carlo Pincelli, Animesh A. Sinha, Eli Sprecher, Detlef Zillikens, Michael Hertl, Jens Waschke

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

Original languageEnglish
Pages (from-to)32-37
Number of pages6
JournalJournal of Investigative Dermatology
Volume138
Issue number1
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Pemphigus
Keratinocytes
Autoantibodies
Desmosomal Cadherins
Desmogleins
Blister
Skin Diseases
Skin
Immunoglobulin G

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

Cite this

Spindler, V., Eming, R., Schmidt, E., Amagai, M., Grando, S., Jonkman, M. F., ... Waschke, J. (2018). Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. Journal of Investigative Dermatology, 138(1), 32-37. https://doi.org/10.1016/j.jid.2017.06.022

Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. / Spindler, Volker; Eming, Rüdiger; Schmidt, Enno; Amagai, Masayuki; Grando, Sergei; Jonkman, Marcel F.; Kowalczyk, Andrew P.; Müller, Eliane J.; Payne, Aimee S.; Pincelli, Carlo; Sinha, Animesh A.; Sprecher, Eli; Zillikens, Detlef; Hertl, Michael; Waschke, Jens.

In: Journal of Investigative Dermatology, Vol. 138, No. 1, 01.01.2018, p. 32-37.

Research output: Contribution to journalReview article

Spindler, V, Eming, R, Schmidt, E, Amagai, M, Grando, S, Jonkman, MF, Kowalczyk, AP, Müller, EJ, Payne, AS, Pincelli, C, Sinha, AA, Sprecher, E, Zillikens, D, Hertl, M & Waschke, J 2018, 'Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus', Journal of Investigative Dermatology, vol. 138, no. 1, pp. 32-37. https://doi.org/10.1016/j.jid.2017.06.022
Spindler, Volker ; Eming, Rüdiger ; Schmidt, Enno ; Amagai, Masayuki ; Grando, Sergei ; Jonkman, Marcel F. ; Kowalczyk, Andrew P. ; Müller, Eliane J. ; Payne, Aimee S. ; Pincelli, Carlo ; Sinha, Animesh A. ; Sprecher, Eli ; Zillikens, Detlef ; Hertl, Michael ; Waschke, Jens. / Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus. In: Journal of Investigative Dermatology. 2018 ; Vol. 138, No. 1. pp. 32-37.
@article{34f981c4b2434cdca08284d55e6581ce,
title = "Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus",
abstract = "The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.",
author = "Volker Spindler and R{\"u}diger Eming and Enno Schmidt and Masayuki Amagai and Sergei Grando and Jonkman, {Marcel F.} and Kowalczyk, {Andrew P.} and M{\"u}ller, {Eliane J.} and Payne, {Aimee S.} and Carlo Pincelli and Sinha, {Animesh A.} and Eli Sprecher and Detlef Zillikens and Michael Hertl and Jens Waschke",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.jid.2017.06.022",
language = "English",
volume = "138",
pages = "32--37",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Mechanisms Causing Loss of Keratinocyte Cohesion in Pemphigus

AU - Spindler, Volker

AU - Eming, Rüdiger

AU - Schmidt, Enno

AU - Amagai, Masayuki

AU - Grando, Sergei

AU - Jonkman, Marcel F.

AU - Kowalczyk, Andrew P.

AU - Müller, Eliane J.

AU - Payne, Aimee S.

AU - Pincelli, Carlo

AU - Sinha, Animesh A.

AU - Sprecher, Eli

AU - Zillikens, Detlef

AU - Hertl, Michael

AU - Waschke, Jens

PY - 2018/1/1

Y1 - 2018/1/1

N2 - The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

AB - The autoimmune blistering skin disease pemphigus is caused by IgG autoantibodies against desmosomal cadherins, but the precise mechanisms are in part a matter of controversial discussions. This review focuses on the currently existing models of the disease and highlights the relevance of desmoglein-specific versus nondesmoglein autoantibodies, the contribution of nonautoantibody factors, and the mechanisms leading to cell dissociation and blister formation in response to autoantibody binding. As the review brings together the majority of laboratories currently working on pemphigus pathogenesis, it aims to serve as a solid basis for further investigations for the entire field.

UR - http://www.scopus.com/inward/record.url?scp=85039948470&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85039948470&partnerID=8YFLogxK

U2 - 10.1016/j.jid.2017.06.022

DO - 10.1016/j.jid.2017.06.022

M3 - Review article

C2 - 29037765

AN - SCOPUS:85039948470

VL - 138

SP - 32

EP - 37

JO - Journal of Investigative Dermatology

JF - Journal of Investigative Dermatology

SN - 0022-202X

IS - 1

ER -