Mechanistic view of renal protective action of calcium channel blockade

Naoki Sugano, Koichi Hayashi, Tatsuo Hosoya, Takashi Yokoo

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Calcium channel blockers are one of the most useful antihypertensive agents because of their definite blood pressure lowering action. Although the antihypertensive effect of calcium channel blockers is attributed predominantly to the blockade of L-type calcium channels, recent studies demonstrate that the blockade of other subtypes of calcium channels, including T-type and N-type calcium channels, offers renal protective action because of their beneficial action on glomerular capillary pressure, renal fibrotic process, sympathetic nerve activity and aldosterone synthesis. It requires more extensive studies to clarify whether the ostensibly beneficial actions of these calcium channel blockers are available in a clinical setting.

Original languageEnglish
Pages (from-to)187-192
Number of pages6
JournalCurrent Hypertension Reviews
Volume9
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Glomerular pressure
  • Renal fibrosis
  • T-type calcium channel

ASJC Scopus subject areas

  • Internal Medicine

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