Mechano-bioscience in heart disease and regenerative medicine

Shota Kurotsu, Masaki Ieda

Research output: Contribution to journalArticle

Abstract

During cardiac development and maturation, the heart continuously receives hemodynamic stimuli, referred to mechanical stress. Mechanical stress governs both cardiac development and differentiation, and also plays an important role in the maintenance of cardiac homeostasis. Indeed, cardiac hypertrophic changes emerge as a result of adaptation to mechanical overload. However, it is difficult to measure the mechanical stress precisely. Therefore, the molecular mechanisms of hemodynamics-related diseases are minimally understood. The progress in mechanobioscience field has a potential to uncover the mechanisms of cardiac diseases, and is expected to result in drug discovery in the future.

Original languageEnglish
Pages (from-to)1697-1702
Number of pages6
JournalClinical calcium
Volume26
Issue number12
Publication statusPublished - 2016 Jan 1

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Kurotsu, S., & Ieda, M. (2016). Mechano-bioscience in heart disease and regenerative medicine. Clinical calcium, 26(12), 1697-1702.