Medical molecular morphology with imaging mass spectrometry

Yoshishige Kimura, Koji Tsutsumi, Yuki Sugiura, Mitsutoshi Setou

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

Imaging mass spectrometry (IMS) is a two-dimensional mass spectrometry to visualize the spatial distribution of biomolecules that does not need either separation or purification of target molecules and enables us to monitor not only the identification of unknown molecules but also the localization of numerous molecules simultaneously. Among the ionization techniques, matrix-assisted laser desorption/ionization (MALDI) is one of those most generally used for IMS, which allows the analysis of numerous biomolecules ranging over wide molecular weights. At present, targets of IMS research have expanded to the imaging of small endogenous metabolites such as lipids, exogenous drug pharmacokinetics, exploring new disease markers, and other new scientific fields.

Original languageEnglish
Pages (from-to)133-137
Number of pages5
JournalMedical Molecular Morphology
Volume42
Issue number3
DOIs
Publication statusPublished - 2009 Sep

Keywords

  • Imaging
  • Imaging mass spectrometry (IMS)
  • Lipids
  • Matrix-assisted laser desorption/ionization (MALDI)
  • Metabolome
  • Nanoparticle-assisted laser desorption ionization (nano-PALDI)
  • Pharmacokinetics

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology

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