TY - JOUR
T1 - Medication Adherence among Patients with Chronic Hepatitis Receiving Antiviral Treatment
AU - Go, Hirofumi
AU - Tanaka, Makoto
AU - Yamamoto-Mitani, Noriko
AU - Suzuki, Miho
AU - Kawakami, Aki
AU - Masaki, Naohiko
AU - Shimada, Megumi
N1 - Funding Information:
This study was a part of a larger study supported by the Ministry of Education, Culture, Sports, Science and Technology under KAKENHI Grant Number 24593313, Tokyo, Japan.
Publisher Copyright:
© 2019 Society of Gastroenterology Nurses and Associates.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - This study aimed to evaluate medication adherence and associated factors among patients with chronic viral hepatitis. A cross-sectional questionnaire survey was conducted in 171 outpatients receiving antiviral treatment of chronic viral hepatitis at 6 national/regional liver disease treatment centers in Japan. Medication adherence was calculated as the subject-reported number of antiviral tablets taken in the past 2 weeks compared with the prescribed number of tablets. Subjects were divided according to 100% adherence or nonadherence. The impact of items pertaining to everyday experiences and perceptions regarding medication adherence were examined. Factors associated with medication adherence were identified via multiple logistic regression. The mean medication adherence rate was 95.8% ± 9.5% (range = 0%-100%), although a smaller proportion (95 subjects; 55.6%) was 100% adherent. Multiple logistic regression indicated a greater "lack of understanding of need for medication" (1 point: odds ratio (OR) = 1.51, 95% confidence interval (CI) [1.30, 1.76], p ≤.01) and greater "restriction in life due to medication" (1 point: OR = 1.26, 95% CI [1.03, 1.54], p = 0.03) as associated with nonadherence. In conclusion, to improve medication adherence, healthcare professionals should improve patients' understanding of the need for medication and minimization of life restrictions.
AB - This study aimed to evaluate medication adherence and associated factors among patients with chronic viral hepatitis. A cross-sectional questionnaire survey was conducted in 171 outpatients receiving antiviral treatment of chronic viral hepatitis at 6 national/regional liver disease treatment centers in Japan. Medication adherence was calculated as the subject-reported number of antiviral tablets taken in the past 2 weeks compared with the prescribed number of tablets. Subjects were divided according to 100% adherence or nonadherence. The impact of items pertaining to everyday experiences and perceptions regarding medication adherence were examined. Factors associated with medication adherence were identified via multiple logistic regression. The mean medication adherence rate was 95.8% ± 9.5% (range = 0%-100%), although a smaller proportion (95 subjects; 55.6%) was 100% adherent. Multiple logistic regression indicated a greater "lack of understanding of need for medication" (1 point: odds ratio (OR) = 1.51, 95% confidence interval (CI) [1.30, 1.76], p ≤.01) and greater "restriction in life due to medication" (1 point: OR = 1.26, 95% CI [1.03, 1.54], p = 0.03) as associated with nonadherence. In conclusion, to improve medication adherence, healthcare professionals should improve patients' understanding of the need for medication and minimization of life restrictions.
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U2 - 10.1097/SGA.0000000000000363
DO - 10.1097/SGA.0000000000000363
M3 - Article
C2 - 30946301
AN - SCOPUS:85064239213
SN - 1042-895X
VL - 42
SP - 140
EP - 149
JO - Gastroenterology Nursing
JF - Gastroenterology Nursing
IS - 2
ER -
