Medulloblastoma in Older Adults

A Case Report and Literature Review

Makoto Murase, Katsuya Saito, Tomohiro Abiko, Kazunari Yoshida, Hideyuki Tomita

Research output: Contribution to journalArticle

Abstract

Background: Medulloblastoma is a malignant tumor of the posterior fossa and is predominantly seen in children younger than 15 years of age. This tumor is uncommon in adults, especially those older than 40 years of age, and reports of cases in patients older than 60 years of age are particularly rare. Although surgery and radiotherapy play important roles in treatment of medulloblastoma in adults, addition of chemotherapy is controversial, especially prior to radiotherapy. Case Description: We present a case of a 63-year-old woman with an atypical medulloblastoma in the cerebellum and a lesion in the suprasellar area that did not appear to be a metastasis of the medulloblastoma. The patient underwent a subtotal resection of the cerebellar medulloblastoma, which was classified histologically as classic subtype and molecularly as non-Wingless/non-Sonic hedgehog subtype in World Health Organization 2016 classification. Then she underwent postoperative chemotherapy followed by radiotherapy. We administered chemotherapy to facilitate therapeutic diagnosis of the suprasellar lesion. The combination treatment resulted in the disappearance of the cerebellar medulloblastoma with treatment toxicity well tolerated. Additionally, the suprasellar lesion remains under control. Conclusions: Even in adults over 60 years of age, medulloblastoma should be included in the differential diagnosis of a cerebellar mass. Chemotherapy for adult medulloblastoma has the potential to be efficacious and tolerable.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalWorld Neurosurgery
Volume117
DOIs
Publication statusPublished - 2018 Sep 1

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Medulloblastoma
Drug Therapy
Radiotherapy
Infratentorial Neoplasms
Therapeutics
Cerebellum
Differential Diagnosis
Neoplasm Metastasis

Keywords

  • Chemotherapy
  • Medulloblastoma
  • Molecular subtype
  • Older adults

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Medulloblastoma in Older Adults : A Case Report and Literature Review. / Murase, Makoto; Saito, Katsuya; Abiko, Tomohiro; Yoshida, Kazunari; Tomita, Hideyuki.

In: World Neurosurgery, Vol. 117, 01.09.2018, p. 25-31.

Research output: Contribution to journalArticle

Murase, Makoto ; Saito, Katsuya ; Abiko, Tomohiro ; Yoshida, Kazunari ; Tomita, Hideyuki. / Medulloblastoma in Older Adults : A Case Report and Literature Review. In: World Neurosurgery. 2018 ; Vol. 117. pp. 25-31.
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