Melatonin as a local regulator of human placental function

Shinya Iwasaki, Kazumi Nakazawa, Jun Sakai, Kunio Kometani, Mitsutoshi Iwashita, Yasunori Yoshimura, Tetsuo Maruyama

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Melatonin plays a critical role in a variety of mammalian reproductive processes not only acting on the central nervous system but also behaving as a peripheral physiologic regulator. To address the relevance of melatonin to the maintenance of pregnancy at the feto-maternal interface, we investigated the expression of two types of membrane melatonin receptors, MT1 and MT2, as well as arylalkylamine N-acetyltransferase (AA-NAT) and hydroxyindole-O-methyltransferase (HIOMT), the two enzymes required for the conversion of serotonin to melatonin, in the human placenta and the effect of melatonin on the release of human chorionic gonadotropin (hCG) from cultured human trophoblast cells. RT-PCR analysis and DNA sequencing revealed that transcripts of MT1, MT2, AA-NAT, and HIOMT were present in the first-trimester human placenta. We also found that melatonin significantly potentiated hCG secretion at optimal concentrations. These results suggest that melatonin may regulate human placental function in a paracrine/autocrine manner, providing evidence for a novel role in human reproduction.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalJournal of Pineal Research
Volume39
Issue number3
DOIs
Publication statusPublished - 2005 Oct

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Melatonin
Acetylserotonin O-Methyltransferase
Arylalkylamine N-Acetyltransferase
Chorionic Gonadotropin
Placenta
Melatonin MT1 Receptor
Melatonin MT2 Receptor
Pregnancy Maintenance
Trophoblasts
First Pregnancy Trimester
DNA Sequence Analysis
Reproduction
Serotonin
Central Nervous System
Mothers
Polymerase Chain Reaction
Membranes
Enzymes

Keywords

  • Human chorionic gonadotropin
  • Melatonin
  • Placenta
  • Trophoblast

ASJC Scopus subject areas

  • Endocrinology

Cite this

Iwasaki, S., Nakazawa, K., Sakai, J., Kometani, K., Iwashita, M., Yoshimura, Y., & Maruyama, T. (2005). Melatonin as a local regulator of human placental function. Journal of Pineal Research, 39(3), 261-265. https://doi.org/10.1111/j.1600-079X.2005.00244.x

Melatonin as a local regulator of human placental function. / Iwasaki, Shinya; Nakazawa, Kazumi; Sakai, Jun; Kometani, Kunio; Iwashita, Mitsutoshi; Yoshimura, Yasunori; Maruyama, Tetsuo.

In: Journal of Pineal Research, Vol. 39, No. 3, 10.2005, p. 261-265.

Research output: Contribution to journalArticle

Iwasaki, S, Nakazawa, K, Sakai, J, Kometani, K, Iwashita, M, Yoshimura, Y & Maruyama, T 2005, 'Melatonin as a local regulator of human placental function', Journal of Pineal Research, vol. 39, no. 3, pp. 261-265. https://doi.org/10.1111/j.1600-079X.2005.00244.x
Iwasaki S, Nakazawa K, Sakai J, Kometani K, Iwashita M, Yoshimura Y et al. Melatonin as a local regulator of human placental function. Journal of Pineal Research. 2005 Oct;39(3):261-265. https://doi.org/10.1111/j.1600-079X.2005.00244.x
Iwasaki, Shinya ; Nakazawa, Kazumi ; Sakai, Jun ; Kometani, Kunio ; Iwashita, Mitsutoshi ; Yoshimura, Yasunori ; Maruyama, Tetsuo. / Melatonin as a local regulator of human placental function. In: Journal of Pineal Research. 2005 ; Vol. 39, No. 3. pp. 261-265.
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