Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture

Yamada Naoshi, Iwasa Hideaki, Mori Shigeo, Kurokawa Norikazu, Masuzawa Toshio, Kazuko Fujimoto, Kawashima Koichiro

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Melatonin (MLT) secretion was examined in six normal pressure hydrocephalus (NPH) patients before and after ventriculoperitoneal (VP) shunt surgery. Ten healthy subjects were used as controls. Venous blood samples were taken daily at 2 p.m., 8 p.m., 2 a.m., and 8 a.m. Radioimmunoassay of MLT used a new specific antiserum and separation method achieving low cross-reactivity and high-efficiency MLT separation. Plasma levels in the control group at 2 p.m. and 2 a.m. were significantly different, showing diurnal rhythm (DR). The patients’ MLT levels before VP shunt were significantly lower than control levels and the DR was absent. Postoperatively, the values were significantly different from preoperative values only at 2 a.m., but the DR reappeared. Thus, in NPH, VP shunt surgery improved the melatonin DR, probably through normalization of the dilated third ventricle.

Original languageEnglish
Pages (from-to)490-497
Number of pages8
JournalNeurologia Medico-Chirurgica
Volume31
Issue number8
DOIs
Publication statusPublished - 1991

Fingerprint

Normal Pressure Hydrocephalus
Intracranial Aneurysm
Melatonin
Rupture
Circadian Rhythm
Ventriculoperitoneal Shunt
Third Ventricle
Radioimmunoassay
Immune Sera
Healthy Volunteers
Control Groups

Keywords

  • diurnal rhythm
  • normal pressure hydrocephalus
  • plasma melatonin
  • ventriculoperitoneal shunt

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

Cite this

Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture. / Naoshi, Yamada; Hideaki, Iwasa; Shigeo, Mori; Norikazu, Kurokawa; Toshio, Masuzawa; Fujimoto, Kazuko; Koichiro, Kawashima.

In: Neurologia Medico-Chirurgica, Vol. 31, No. 8, 1991, p. 490-497.

Research output: Contribution to journalArticle

Naoshi, Y, Hideaki, I, Shigeo, M, Norikazu, K, Toshio, M, Fujimoto, K & Koichiro, K 1991, 'Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture', Neurologia Medico-Chirurgica, vol. 31, no. 8, pp. 490-497. https://doi.org/10.2176/nmc.31.490
Naoshi, Yamada ; Hideaki, Iwasa ; Shigeo, Mori ; Norikazu, Kurokawa ; Toshio, Masuzawa ; Fujimoto, Kazuko ; Koichiro, Kawashima. / Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture. In: Neurologia Medico-Chirurgica. 1991 ; Vol. 31, No. 8. pp. 490-497.
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