TY - JOUR
T1 - Melatonin Secretion in Normal Pressure Hydrocephalus After Cerebral Aneurysm Rupture
AU - Naoshi, Yamada
AU - Hideaki, Iwasa
AU - Shigeo, Mori
AU - Norikazu, Kurokawa
AU - Toshio, Masuzawa
AU - Kazuko, Fujimoto
AU - Koichiro, Kawashima
PY - 1991
Y1 - 1991
N2 - Melatonin (MLT) secretion was examined in six normal pressure hydrocephalus (NPH) patients before and after ventriculoperitoneal (VP) shunt surgery. Ten healthy subjects were used as controls. Venous blood samples were taken daily at 2 p.m., 8 p.m., 2 a.m., and 8 a.m. Radioimmunoassay of MLT used a new specific antiserum and separation method achieving low cross-reactivity and high-efficiency MLT separation. Plasma levels in the control group at 2 p.m. and 2 a.m. were significantly different, showing diurnal rhythm (DR). The patients’ MLT levels before VP shunt were significantly lower than control levels and the DR was absent. Postoperatively, the values were significantly different from preoperative values only at 2 a.m., but the DR reappeared. Thus, in NPH, VP shunt surgery improved the melatonin DR, probably through normalization of the dilated third ventricle.
AB - Melatonin (MLT) secretion was examined in six normal pressure hydrocephalus (NPH) patients before and after ventriculoperitoneal (VP) shunt surgery. Ten healthy subjects were used as controls. Venous blood samples were taken daily at 2 p.m., 8 p.m., 2 a.m., and 8 a.m. Radioimmunoassay of MLT used a new specific antiserum and separation method achieving low cross-reactivity and high-efficiency MLT separation. Plasma levels in the control group at 2 p.m. and 2 a.m. were significantly different, showing diurnal rhythm (DR). The patients’ MLT levels before VP shunt were significantly lower than control levels and the DR was absent. Postoperatively, the values were significantly different from preoperative values only at 2 a.m., but the DR reappeared. Thus, in NPH, VP shunt surgery improved the melatonin DR, probably through normalization of the dilated third ventricle.
KW - diurnal rhythm
KW - normal pressure hydrocephalus
KW - plasma melatonin
KW - ventriculoperitoneal shunt
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U2 - 10.2176/nmc.31.490
DO - 10.2176/nmc.31.490
M3 - Article
C2 - 1722876
AN - SCOPUS:0025917332
SN - 0470-8105
VL - 31
SP - 490
EP - 497
JO - Neurologia Medico-Chirurgica
JF - Neurologia Medico-Chirurgica
IS - 8
ER -