Melon GliSODin® prevents diet-induced NASH onset by reducing fat synthesis and improving liver function

Anna Nakamura, Naho Kitamura, Yoko Yokoyama, Sena Uchida, Kayo Kumadaki, Kazuo Tsubota, Mitsuhiro Watanabe

Research output: Contribution to journalArticle

Abstract

A high-calorie diet causes fat accumulation and oxidative stress in the liver, leading to fatty liver and eventually non-alcoholic steatohepatitis (NASH). Melon GliSODin® is used as a nutritional supplement because of its antioxidant activity. This study aimed to assess the antioxidant activity of Melon GliSODin® and its effectiveness in preventing NASH, which primarily results from oxidative stress. Furthermore, we verified the protective effect of Melon GliSODin® by administering it to a mouse model of diet-induced NASH. Melon GliSODin® suppressed liver fibrosis and fat accumulation, which is characteristic of the NASH phenotype. Gene expression analysis confirmed the suppression of fat synthesis and activation of antioxidative mechanisms. These results show that Melon GliSODin® mitigates NASH onset at the molecular level, suggesting its potential application as a NASH preventive agent.

Original languageEnglish
Article number1779
JournalNutrients
Volume11
Issue number8
DOIs
Publication statusPublished - 2019 Aug

Keywords

  • Liver disease
  • Natural products
  • Non-alcoholic fatty liver disease
  • Non-alcoholic steatohepatitis
  • Oxidative stress

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics

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