Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection

Ayako Nakajima, Masayuki Adachi, Michi Tanaka, Akira Suwa, Yoshihiro Yasuki, Hiroyuki Imaeda, Shinichi Inada

Research output: Contribution to journalArticle

2 Citations (Scopus)


The etiopathogenesis of extrahepatic manifestations including vasculitis in the context of HCV infection is still unknown. We report a case with lethal extrahepatic manifestations due to chronic hepatitis C virus (HCV) infection. The patient presented leukocytoclastic vasculitis, sensorimotor neuropathy and membranoproliferative glomerulonephritis with positive rheumatoid factor but lacked cryoglobulin. Hypocomplementaemia and deposition of IgM and C3 in the vascular lesion and glomeruli suggested that immune complex disease played a role in the pathogenesis of extrahepatic manifestations independent of cryoglobulin. Although HCV was successfully eliminated by treatment with interferon α, she died of cryptococcal infection.

Original languageEnglish
Pages (from-to)1042-1046
Number of pages5
JournalInternal Medicine
Issue number10
Publication statusPublished - 2003 Oct



  • Cryptococcus
  • Extrahepatic manifestations
  • Immune complex disease
  • Interferon α
  • Opportunistic infection

ASJC Scopus subject areas

  • Internal Medicine

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