Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection

Ayako Nakajima, Masayuki Adachi, Michi Tanaka, Akira Suwa, Yoshihiro Yasuki, Hiroyuki Imaeda, Shinichi Inada

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The etiopathogenesis of extrahepatic manifestations including vasculitis in the context of HCV infection is still unknown. We report a case with lethal extrahepatic manifestations due to chronic hepatitis C virus (HCV) infection. The patient presented leukocytoclastic vasculitis, sensorimotor neuropathy and membranoproliferative glomerulonephritis with positive rheumatoid factor but lacked cryoglobulin. Hypocomplementaemia and deposition of IgM and C3 in the vascular lesion and glomeruli suggested that immune complex disease played a role in the pathogenesis of extrahepatic manifestations independent of cryoglobulin. Although HCV was successfully eliminated by treatment with interferon α, she died of cryptococcal infection.

Original languageEnglish
Pages (from-to)1042-1046
Number of pages5
JournalInternal Medicine
Volume42
Issue number10
Publication statusPublished - 2003 Oct

Fingerprint

Cryoglobulins
Membranoproliferative Glomerulonephritis
Chronic Hepatitis C
Virus Diseases
Hepacivirus
Immune Complex Diseases
Rheumatoid Factor
Vasculitis
Interferons
Immunoglobulin M
Blood Vessels
Infection
Erythema elevatum diutinum
Therapeutics

Keywords

  • Cryptococcus
  • Extrahepatic manifestations
  • Immune complex disease
  • Interferon α
  • Opportunistic infection

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Nakajima, A., Adachi, M., Tanaka, M., Suwa, A., Yasuki, Y., Imaeda, H., & Inada, S. (2003). Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection. Internal Medicine, 42(10), 1042-1046.

Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection. / Nakajima, Ayako; Adachi, Masayuki; Tanaka, Michi; Suwa, Akira; Yasuki, Yoshihiro; Imaeda, Hiroyuki; Inada, Shinichi.

In: Internal Medicine, Vol. 42, No. 10, 10.2003, p. 1042-1046.

Research output: Contribution to journalArticle

Nakajima, A, Adachi, M, Tanaka, M, Suwa, A, Yasuki, Y, Imaeda, H & Inada, S 2003, 'Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection', Internal Medicine, vol. 42, no. 10, pp. 1042-1046.
Nakajima, Ayako ; Adachi, Masayuki ; Tanaka, Michi ; Suwa, Akira ; Yasuki, Yoshihiro ; Imaeda, Hiroyuki ; Inada, Shinichi. / Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection. In: Internal Medicine. 2003 ; Vol. 42, No. 10. pp. 1042-1046.
@article{623df5a3b8464c64881542cd845c7016,
title = "Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection",
abstract = "The etiopathogenesis of extrahepatic manifestations including vasculitis in the context of HCV infection is still unknown. We report a case with lethal extrahepatic manifestations due to chronic hepatitis C virus (HCV) infection. The patient presented leukocytoclastic vasculitis, sensorimotor neuropathy and membranoproliferative glomerulonephritis with positive rheumatoid factor but lacked cryoglobulin. Hypocomplementaemia and deposition of IgM and C3 in the vascular lesion and glomeruli suggested that immune complex disease played a role in the pathogenesis of extrahepatic manifestations independent of cryoglobulin. Although HCV was successfully eliminated by treatment with interferon α, she died of cryptococcal infection.",
keywords = "Cryptococcus, Extrahepatic manifestations, Immune complex disease, Interferon α, Opportunistic infection",
author = "Ayako Nakajima and Masayuki Adachi and Michi Tanaka and Akira Suwa and Yoshihiro Yasuki and Hiroyuki Imaeda and Shinichi Inada",
year = "2003",
month = "10",
language = "English",
volume = "42",
pages = "1042--1046",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "10",

}

TY - JOUR

T1 - Membranoproliferative glomerulonephritis and leukocytoclastic vasculitis without cryoglobulin in chronic hepatitis C virus infection

AU - Nakajima, Ayako

AU - Adachi, Masayuki

AU - Tanaka, Michi

AU - Suwa, Akira

AU - Yasuki, Yoshihiro

AU - Imaeda, Hiroyuki

AU - Inada, Shinichi

PY - 2003/10

Y1 - 2003/10

N2 - The etiopathogenesis of extrahepatic manifestations including vasculitis in the context of HCV infection is still unknown. We report a case with lethal extrahepatic manifestations due to chronic hepatitis C virus (HCV) infection. The patient presented leukocytoclastic vasculitis, sensorimotor neuropathy and membranoproliferative glomerulonephritis with positive rheumatoid factor but lacked cryoglobulin. Hypocomplementaemia and deposition of IgM and C3 in the vascular lesion and glomeruli suggested that immune complex disease played a role in the pathogenesis of extrahepatic manifestations independent of cryoglobulin. Although HCV was successfully eliminated by treatment with interferon α, she died of cryptococcal infection.

AB - The etiopathogenesis of extrahepatic manifestations including vasculitis in the context of HCV infection is still unknown. We report a case with lethal extrahepatic manifestations due to chronic hepatitis C virus (HCV) infection. The patient presented leukocytoclastic vasculitis, sensorimotor neuropathy and membranoproliferative glomerulonephritis with positive rheumatoid factor but lacked cryoglobulin. Hypocomplementaemia and deposition of IgM and C3 in the vascular lesion and glomeruli suggested that immune complex disease played a role in the pathogenesis of extrahepatic manifestations independent of cryoglobulin. Although HCV was successfully eliminated by treatment with interferon α, she died of cryptococcal infection.

KW - Cryptococcus

KW - Extrahepatic manifestations

KW - Immune complex disease

KW - Interferon α

KW - Opportunistic infection

UR - http://www.scopus.com/inward/record.url?scp=0242690508&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242690508&partnerID=8YFLogxK

M3 - Article

C2 - 14606724

AN - SCOPUS:0242690508

VL - 42

SP - 1042

EP - 1046

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 10

ER -