Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus

Hidehiko Takahashi, Motoichiro Kato, Mika Hayashi, Yoshiro Okubo, Akihiro Takano, Hiroshi Ito, Tetsuya Suhara

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Cerebral cortical regions are thought to be important for cognitive functions such as memory and executive function. Although the functional associations between dopamine D2 receptors and motor and cognitive functions have been extensively examined in the striatum using positron emission tomography (PET), the role of dopamine D2 receptors in extrastriatal regions has been unexplored. We aimed to investigate the relationship between dopamine D2 receptors in extrastriatal regions and the performance of a broad spectrum of cognitive functions including memory, language, attention, and executive function in healthy subjects. Extrastriatal dopamine D2 receptors were measured in 25 male subjects using PET with [11C]FLB457. After the PET scans, a battery of neuropsychological tests was administered to all subjects. We found that the binding potential (BP) of [11C]FLB457 in the hippocampus was positively correlated with memory function. Furthermore, BP of [11C]FLB457 in the hippocampus, but not in the prefrontal cortex, was associated with frontal lobe functions such as executive function and verbal fluency. Our findings suggest that dopamine D2 receptors in the hippocampus might affect the local hippocampal function, but also brain functions outside the hippocampus such as the prefrontal cortex.

Original languageEnglish
Pages (from-to)1643-1649
Number of pages7
JournalNeuroImage
Volume34
Issue number4
DOIs
Publication statusPublished - 2007 Feb 15

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Dopamine D2 Receptors
Frontal Lobe
Hippocampus
Executive Function
Positron-Emission Tomography
Cognition
Prefrontal Cortex
Neuropsychological Tests
Healthy Volunteers
Language
Brain

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Takahashi, H., Kato, M., Hayashi, M., Okubo, Y., Takano, A., Ito, H., & Suhara, T. (2007). Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus. NeuroImage, 34(4), 1643-1649. https://doi.org/10.1016/j.neuroimage.2006.11.008

Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus. / Takahashi, Hidehiko; Kato, Motoichiro; Hayashi, Mika; Okubo, Yoshiro; Takano, Akihiro; Ito, Hiroshi; Suhara, Tetsuya.

In: NeuroImage, Vol. 34, No. 4, 15.02.2007, p. 1643-1649.

Research output: Contribution to journalArticle

Takahashi, H, Kato, M, Hayashi, M, Okubo, Y, Takano, A, Ito, H & Suhara, T 2007, 'Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus', NeuroImage, vol. 34, no. 4, pp. 1643-1649. https://doi.org/10.1016/j.neuroimage.2006.11.008
Takahashi, Hidehiko ; Kato, Motoichiro ; Hayashi, Mika ; Okubo, Yoshiro ; Takano, Akihiro ; Ito, Hiroshi ; Suhara, Tetsuya. / Memory and frontal lobe functions; possible relations with dopamine D2 receptors in the hippocampus. In: NeuroImage. 2007 ; Vol. 34, No. 4. pp. 1643-1649.
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