Memory Impairment and Awareness of Memory Deficits in Early-Stage Alzheimer's Disease

Masaru Mimura, Madoka Yano

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Recognition memory of auditory verbal learning tests and awareness of memory deficits were examined in 24 individuals with earlystage Alzheimer's disease (AD) using a performance prediction-postdiction paradigm. Individuals with AD displayed impaired recognition memory, and recognition performance correlated positively with regional cerebral blood flow at rest in bilateral prefrontal areas and the left medial temporal area. In addition, underawareness of memory deficits was also marked even at this early stage. Individuals with AD retrospectively overestimated memory performance after actual performance, but appeared to benefit from feedback, and displayed intact online awareness of memory dysfunction, leading to normal prediction of the second session. However, individuals with AD failed to retrospectively incorporate incidents of memory failure into generalized self-belief systems. Brain/behavior correlational analyses suggest that the prefrontal cortex and posterior dorsomedial regions including the precuneus may be involved in self-awareness.

Original languageEnglish
Pages (from-to)253-266
Number of pages14
JournalReviews in the Neurosciences
Volume17
Issue number1-2
DOIs
Publication statusPublished - 2006 Jan 1
Externally publishedYes

Keywords

  • Alzheimer's disease
  • SPECT
  • awareness
  • frontal lobe
  • hippocampus
  • memory impairment
  • precuneus
  • recognition

ASJC Scopus subject areas

  • Neuroscience(all)

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