Meningitis caused by Listeria monocytogenes in a locally advanced cervical cancer patient with pyometra: A case report

Yusuke Matoba, Hiroshi Nishio, Koji Sekiguchi, Shunsuke Uno, Kenta Masuda, Makiko Hiramatsu, Mio Takahashi, Maki Oishi, Yoshifumi Uwamino, Sho Uchida, Yugaku Daté, Tohru Morisada, Kouji Banno, Jin Nakahara, Daisuke Aoki

Research output: Contribution to journalArticlepeer-review

Abstract

Locally advanced cervical cancer occasionally induces pyometra, but there have been no reports of meningitis where pyometra is the cause of infection. Here, we report a case of Listeria monocytogenes meningitis related to pyometra during concurrent chemoradiotherapy (CCRT) in a cervical cancer patient. The patient, a 77-year-old woman, was diagnosed with Stage IIB (FIGO 2018) cervical adenocarcinoma, and CCRT was initiated. Pyometra was exacerbated during CCRT, and after her first brachytherapy, she presented at our hospital with fever and decreased consciousness level. After admission to the Intensive Care Unit, the patient lost consciousness and experienced frequent seizures; tracheal intubation was required. Whole-body computed tomography revealed pyometra; therefore, transvaginal removal of the abscess was performed. Laboratory tests and vital signs indicated septic shock, and meropenem was administered. L. monocytogenes was detected in the abscess from the uterine cavity and the blood cultures on the third day of hospitalization. A lumbar puncture was performed on the same day to investigate whether the patient had meningitis. A FilmArray meningitis/encephalitis panel test of the spinal fluid revealed L. monocytogenes. After the diagnosis of meningitis with L. monocytogenes, ampicillin and gentamicin were started, and the blood test results gradually improved. Five months after the initial episode, her consciousness recovered, however she still received mechanical ventilatory support. L. monocytogenes infections can occur in patients undergoing chemotherapy, even without the use of steroids or immunosuppressive agents. In cases with pyometra, intrauterine manipulation can increase the risk of severe infection.

Original languageEnglish
Article number100799
JournalGynecologic Oncology Reports
Volume37
DOIs
Publication statusPublished - 2021 Aug

Keywords

  • Cervical cancer
  • Concurrent chemoradiotherapy
  • Listeria monocytogenes
  • Meningitis
  • Pyometra

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynaecology

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