Mesenchymal stem cells: Mechanisms of immunomodulation and homing

Hiroshi Yagi, Alejandro Soto-Gutierrez, Biju Parekkadan, Yuukou Kitagawa, Ronald G. Tompkins, Naoya Kobayashi, Martin L. Yarmush

Research output: Contribution to journalArticle

417 Citations (Scopus)

Abstract

Mesenchymal stem cell (MSC) transplantation has been explored as a new clinical approach to repair injured tissue. A growing corpus of studies have highlighted two important aspects of MSC therapy: 1) MSCs can modulate T-cell-mediated immunological responses, and (2) systemically administered MSCs home to sites of ischemia or injury. In this review, we describe the known mechanisms of immunomodulation and homing of MSCs. First, we examine the low immunogenicity of MSCs and their antigen presentation capabilities. Next, we discuss the paracrine interactions between MSCs and innate [dendritic cells (DC)] and adaptive immune cells (T lymphocytes) with a focus on prostaglandin E2 (PGE2), indoleamine 2,3-dioxygenase (IDO), and toll-like receptor (TLR) signaling pathways. We transition to outline the steps of activation, rolling/ adhesion, and transmigration of MSCs into target tissues during inflammatory or ischemic conditions. These aspects of MSC grafts - immunomodulation and homing - are contextualized to understand a reported side effect of MSC therapy, cancer development.

Original languageEnglish
Pages (from-to)667-679
Number of pages13
JournalCell Transplantation
Volume19
Issue number6-7
DOIs
Publication statusPublished - 2010

Fingerprint

Immunomodulation
Stem cells
Mesenchymal Stromal Cells
Cell- and Tissue-Based Therapy
T-cells
Mesenchymal Stem Cell Transplantation
Indoleamine-Pyrrole 2,3,-Dioxygenase
T-Lymphocytes
Toll-Like Receptors
Antigen Presentation
Tissue
Dinoprostone
Dendritic Cells
Antigens
Ischemia
Grafts
Transplants
Repair
Adhesion
Chemical activation

Keywords

  • Immunosuppression
  • Interferon-γ (IFN-γ)
  • Nuclear factor-κB (NF-κB)
  • Stem cell migration
  • T-cell proliferation

ASJC Scopus subject areas

  • Cell Biology
  • Transplantation
  • Biomedical Engineering

Cite this

Yagi, H., Soto-Gutierrez, A., Parekkadan, B., Kitagawa, Y., Tompkins, R. G., Kobayashi, N., & Yarmush, M. L. (2010). Mesenchymal stem cells: Mechanisms of immunomodulation and homing. Cell Transplantation, 19(6-7), 667-679. https://doi.org/10.3727/096368910X508762

Mesenchymal stem cells : Mechanisms of immunomodulation and homing. / Yagi, Hiroshi; Soto-Gutierrez, Alejandro; Parekkadan, Biju; Kitagawa, Yuukou; Tompkins, Ronald G.; Kobayashi, Naoya; Yarmush, Martin L.

In: Cell Transplantation, Vol. 19, No. 6-7, 2010, p. 667-679.

Research output: Contribution to journalArticle

Yagi, H, Soto-Gutierrez, A, Parekkadan, B, Kitagawa, Y, Tompkins, RG, Kobayashi, N & Yarmush, ML 2010, 'Mesenchymal stem cells: Mechanisms of immunomodulation and homing', Cell Transplantation, vol. 19, no. 6-7, pp. 667-679. https://doi.org/10.3727/096368910X508762
Yagi, Hiroshi ; Soto-Gutierrez, Alejandro ; Parekkadan, Biju ; Kitagawa, Yuukou ; Tompkins, Ronald G. ; Kobayashi, Naoya ; Yarmush, Martin L. / Mesenchymal stem cells : Mechanisms of immunomodulation and homing. In: Cell Transplantation. 2010 ; Vol. 19, No. 6-7. pp. 667-679.
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