Meta-Analysis

Effects of probiotic supplementation on lipid profiles in normal to mildly hypercholesterolemic individuals

Mikiko Shimizu, Masayuki Hashiguchi, Tsuyoshi Shiga, Hiroomi Tamura, Mayumi Mochizuki

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Introduction Recent experimental and clinical studies have suggested that probiotic supplementation has beneficial effects on serum lipid profiles. However, there are conflicting results on the efficacy of probiotic preparations in reducing serum cholesterol. Objective To evaluate the effects of probiotics on human serum lipid levels, we conducted a metaanalysis of interventional studies. Methods Eligible reports were obtained by searches of electronic databases. We included randomized, controlled clinical trials comparing probiotic supplementation with placebo or no treatment (control). Statistical analysis was performed with Review Manager 5.3.3. Subanalyses were also performed. Results Eleven of 33 randomized clinical trials retrieved were eligible for inclusion in the meta-Analysis. No participant had received any cholesterol-lowering agent. Probiotic interventions (including fermented milk products and probiotics) produced changes in total cholesterol (TC) (mean difference-0.17 mmol/L, 95% CI:-0.27 to-0.07 mmol/L) and low-density lipoprotein cholesterol (LDL-C) (mean difference-0.22 mmol/L, 95% CI:-0.30 to-0.13 mmol/ L). High-density lipoprotein cholesterol and triglyceride levels did not differ significantly between probiotic and control groups. In subanalysis, long-Term (>4-week) probiotic intervention was statistically more effective in decreasing TC and LDL-C than short-Term (4-week) intervention. The decreases in TC and LDL-C levels with probiotic intervention were greater in mildly hypercholesterolemic than in normocholesterolemic individuals. Both fermented milk product and probiotic preparations decreased TC and LDL-C levels. Gaio and the Lactobacillus acidophilus strain reduced TC and LDL-C levels to a greater extent than other bacterial strains. Conclusions In conclusion, this meta-Analysis showed that probiotic supplementation could be useful in the primary prevention of hypercholesterolemia and may lead to reductions in risk factors for cardiovascular disease.

Original languageEnglish
Article numbere0139795
JournalPLoS One
Volume10
Issue number10
DOIs
Publication statusPublished - 2015 Oct 16

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Probiotics
meta-analysis
probiotics
Meta-Analysis
Lipids
lipids
Cholesterol
low density lipoprotein cholesterol
LDL Cholesterol
cholesterol
Fermented milk
Cultured Milk Products
randomized clinical trials
fermented milk
blood lipids
dairy products
Randomized Controlled Trials
Serum
Lactobacillus acidophilus
hypercholesterolemia

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Meta-Analysis : Effects of probiotic supplementation on lipid profiles in normal to mildly hypercholesterolemic individuals. / Shimizu, Mikiko; Hashiguchi, Masayuki; Shiga, Tsuyoshi; Tamura, Hiroomi; Mochizuki, Mayumi.

In: PLoS One, Vol. 10, No. 10, e0139795, 16.10.2015.

Research output: Contribution to journalArticle

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