Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population

Yukinori Okada, Chikashi Terao, Katsunori Ikari, Yuta Kochi, Koichiro Ohmura, Akari Suzuki, Takahisa Kawaguchi, Eli A. Stahl, Fina A.S. Kurreeman, Nao Nishida, Hiroko Ohmiya, Keiko Myouzen, Meiko Takahashi, Tetsuji Sawada, Yuichi Nishioka, Masao Yukioka, Tsukasa Matsubara, Shigeyuki Wakitani, Ryota Teshima, Shigeto TohmaKiyoshi Takasugi, Kota Shimada, Akira Murasawa, Shigeru Honjo, Keitaro Matsuo, Hideo Tanaka, Kazuo Tajima, Taku Suzuki, Takuji Iwamoto, Yoshiya Kawamura, Hisashi Tanii, Yuji Okazaki, Tsukasa Sasaki, Peter K. Gregersen, Leonid Padyukov, Jane Worthington, Katherine A. Siminovitch, Mark Lathrop, Atsuo Taniguchi, Atsushi Takahashi, Katsushi Tokunaga, Michiaki Kubo, Yusuke Nakamura, Naoyuki Kamatani, Tsuneyo Mimori, Robert M. Plenge, Hisashi Yamanaka, Shigeki Momohara, Ryo Yamada, Fumihiko Matsuda, Kazuhiko Yamamoto

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Abstract

Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10 -8, including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves′ disease (P = 3.5 × 10 -4 and 2.9 × 10 -4, respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations.

Original languageEnglish
Pages (from-to)511-516
Number of pages6
JournalNature genetics
Volume44
Issue number5
DOIs
Publication statusPublished - 2012 May 1

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ASJC Scopus subject areas

  • Genetics

Cite this

Okada, Y., Terao, C., Ikari, K., Kochi, Y., Ohmura, K., Suzuki, A., Kawaguchi, T., Stahl, E. A., Kurreeman, F. A. S., Nishida, N., Ohmiya, H., Myouzen, K., Takahashi, M., Sawada, T., Nishioka, Y., Yukioka, M., Matsubara, T., Wakitani, S., Teshima, R., ... Yamamoto, K. (2012). Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nature genetics, 44(5), 511-516. https://doi.org/10.1038/ng.2231