Meta-analysis of three diabetes population studies: Association of inactive ALDH2 genotype with maternal inheritance of diabetes

C. Murata, M. Taniyama, S. Kuriyama, T. Muramatsu, Y. Atsumi, K. Matsuoka, Y. Suzuki

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To date, there have been three population studies that examined the association of mitochondrial aldehyde dehydrogenase 2 (ALDH2) genotype with inheritance of diabetes. Here, we summarize the results by meta-analysis. The study 1 consisted of 212 type 2 diabetics who did not have renal failure. The study 2 consisted of 73 type 2 diabetics who had renal failure. The study 3 consisted of 230 type 1 diabetics. In total, 515 subjects were examined for the association of ALDH2 genotype with inheritance of diabetes. Out of 515 subjects, 307 (60%) had active ALDH2 (ALDH2*1/ALDH2*1) and 208 (40%) had inactive ALDH2 (175 had ALDH2*1/ALDH2 *2 and 33 had ALDH2*2/ALDH2 *2). As for family history, 25 subjects (8.1%) in the active ALDH2 group had a diabetic mother, compared with 43 (20.6%) in the inactive ALDH2 group. Twenty-nine subjects (9.4%) in the active ALDH2 group had a diabetic father, compared with 14 (6.7%) in the inactive ALDH2 group. The percentage of diabetic mother was higher in the inactive ALDH2 group, the differences were statistically significant (P < 0.0001). We hence speculate that diabetic patients with inactive ALDH2 genotype may have underlying background of mitochondria etiology, thereby showing maternal trait of diabetes inheritance. In conclusion, meta-analysis using three diabetes population studies strongly confirmed the association between ALDH2 inactivity and maternal inheritance.

Original languageEnglish
Pages (from-to)S145-S147
JournalDiabetes Research and Clinical Practice
Volume66
Issue numberSUPPL.
DOIs
Publication statusPublished - 2004 Dec 1

Keywords

  • 4-Hydroxynonenal
  • Aldehyde dehydrogenase
  • Chlorpropamide alcohol flushing
  • Lipid peroxidation
  • Maternal inheritance
  • Mitochondria

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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