Metabolic regulation of hematopoietic stem cells in the hypoxic niche

Toshio Suda, Keiyo Takubo, Gregg L. Semenza

Research output: Contribution to journalArticle

407 Citations (Scopus)

Abstract

Tissue homeostasis over the life of an organism relies on both self-renewal and multipotent differentiation of stem cells. Hematopoietic stem cells (HSCs) reside in a hypoxic bone marrow environment, and their metabolic status is distinct from that of their differentiated progeny. HSCs generate energy mainly via anaerobic metabolism by maintaining a high rate of glycolysis. This metabolic balance promotes HSC maintenance by limiting the production of reactive oxygen species, but leaves HSCs susceptible to changes in redox status. In this review, we discuss the importance of oxygen homeostasis and energy metabolism for maintenance of HSC function and long-term self-renewal.

Original languageEnglish
Pages (from-to)298-310
Number of pages13
JournalCell Stem Cell
Volume9
Issue number4
DOIs
Publication statusPublished - 2011 Oct 4

Fingerprint

Hematopoietic Stem Cells
Homeostasis
Maintenance
Multipotent Stem Cells
Anaerobiosis
Glycolysis
Energy Metabolism
Oxidation-Reduction
Reactive Oxygen Species
Bone Marrow
Oxygen

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Medicine
  • Genetics

Cite this

Metabolic regulation of hematopoietic stem cells in the hypoxic niche. / Suda, Toshio; Takubo, Keiyo; Semenza, Gregg L.

In: Cell Stem Cell, Vol. 9, No. 4, 04.10.2011, p. 298-310.

Research output: Contribution to journalArticle

Suda, Toshio ; Takubo, Keiyo ; Semenza, Gregg L. / Metabolic regulation of hematopoietic stem cells in the hypoxic niche. In: Cell Stem Cell. 2011 ; Vol. 9, No. 4. pp. 298-310.
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