Metabolic studies of galactosemic cataract

Hong Ming Cheng; Hua Xiong; Jing Xiong; Kazuo Tsubota

doi:10.1016/0014-4835(90)90147-M

Metabolic studies of galactosemic cataract

Hong Ming Cheng, Hua Xiong, Jing Xiong, Kazuo Tsubota

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Experimental diabetic and galactosemic animal models are widely used to study diabetes-induced complications. Galactose feeding can rapidly produce cataract, retinopathy and nephropathy; it is therefore favored over the diabetic model. Although the common feature for both models is the activation of aldose reductase, there are substantial differences between the two-not only does the rate of cataract progression differ but the metabolic patterns are far more complex than for polyol production alone. We here present the result of a comparison between diabetic and galactosemic lenses and show the differences in phosphorus and aldose metabolism, cell integrity and osmotic environment.

Original language	English
Pages (from-to)	345-349
Number of pages	5
Journal	Experimental Eye Research
Volume	51
Issue number	4
DOIs	https://doi.org/10.1016/0014-4835(90)90147-M
Publication status	Published - 1990 Oct
Externally published	Yes

Keywords

NMR
diabetes mellitus
galactosemic cataract
lens
polyol pathway

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0014-4835(90)90147-M

Cite this

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title = "Metabolic studies of galactosemic cataract",

abstract = "Experimental diabetic and galactosemic animal models are widely used to study diabetes-induced complications. Galactose feeding can rapidly produce cataract, retinopathy and nephropathy; it is therefore favored over the diabetic model. Although the common feature for both models is the activation of aldose reductase, there are substantial differences between the two-not only does the rate of cataract progression differ but the metabolic patterns are far more complex than for polyol production alone. We here present the result of a comparison between diabetic and galactosemic lenses and show the differences in phosphorus and aldose metabolism, cell integrity and osmotic environment.",

keywords = "NMR, diabetes mellitus, galactosemic cataract, lens, polyol pathway",

author = "Cheng, {Hong Ming} and Hua Xiong and Jing Xiong and Kazuo Tsubota",

note = "Funding Information: This project was supported by grant No. EY04424, awarded by the National Eye Institute, National Institutes of Health, Bethesda, MD. NMR studies were conducted at Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology, which is supported by RR00995 from the National Institutes of Health.",

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doi = "10.1016/0014-4835(90)90147-M",

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T1 - Metabolic studies of galactosemic cataract

AU - Cheng, Hong Ming

AU - Xiong, Hua

AU - Xiong, Jing

AU - Tsubota, Kazuo

N1 - Funding Information: This project was supported by grant No. EY04424, awarded by the National Eye Institute, National Institutes of Health, Bethesda, MD. NMR studies were conducted at Francis Bitter National Magnet Laboratory, Massachusetts Institute of Technology, which is supported by RR00995 from the National Institutes of Health.

PY - 1990/10

Y1 - 1990/10

N2 - Experimental diabetic and galactosemic animal models are widely used to study diabetes-induced complications. Galactose feeding can rapidly produce cataract, retinopathy and nephropathy; it is therefore favored over the diabetic model. Although the common feature for both models is the activation of aldose reductase, there are substantial differences between the two-not only does the rate of cataract progression differ but the metabolic patterns are far more complex than for polyol production alone. We here present the result of a comparison between diabetic and galactosemic lenses and show the differences in phosphorus and aldose metabolism, cell integrity and osmotic environment.

AB - Experimental diabetic and galactosemic animal models are widely used to study diabetes-induced complications. Galactose feeding can rapidly produce cataract, retinopathy and nephropathy; it is therefore favored over the diabetic model. Although the common feature for both models is the activation of aldose reductase, there are substantial differences between the two-not only does the rate of cataract progression differ but the metabolic patterns are far more complex than for polyol production alone. We here present the result of a comparison between diabetic and galactosemic lenses and show the differences in phosphorus and aldose metabolism, cell integrity and osmotic environment.

KW - NMR

KW - diabetes mellitus

KW - galactosemic cataract

KW - lens

KW - polyol pathway

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Metabolic studies of galactosemic cataract

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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