Metabolic studies of galactosemic cataract

Hong Ming Cheng, Hua Xiong, Jing Xiong, Kazuo Tsubota

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19 Citations (Scopus)

Abstract

Experimental diabetic and galactosemic animal models are widely used to study diabetes-induced complications. Galactose feeding can rapidly produce cataract, retinopathy and nephropathy; it is therefore favored over the diabetic model. Although the common feature for both models is the activation of aldose reductase, there are substantial differences between the two-not only does the rate of cataract progression differ but the metabolic patterns are far more complex than for polyol production alone. We here present the result of a comparison between diabetic and galactosemic lenses and show the differences in phosphorus and aldose metabolism, cell integrity and osmotic environment.

Original languageEnglish
Pages (from-to)345-349
Number of pages5
JournalExperimental Eye Research
Volume51
Issue number4
DOIs
Publication statusPublished - 1990 Oct
Externally publishedYes

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Keywords

  • NMR
  • diabetes mellitus
  • galactosemic cataract
  • lens
  • polyol pathway

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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