Metabolism of human pluripotent stem cells and differentiated cells for regenerative therapy: a focus on cardiomyocytes

Sho Tanosaki, Shugo Tohyama, Yoshikazu Kishino, Jun Fujita, Keiichi Fukuda

Research output: Contribution to journalReview articlepeer-review

Abstract

Pluripotent stem cells (PSCs) exhibit promising application in regenerative therapy, drug discovery, and disease modeling. While several protocols for differentiating somatic cells from PSCs exist, their use is limited by contamination of residual undifferentiated PSCs and immaturity of differentiated somatic cells. The metabolism of PSCs differs greatly from that of somatic cells, and a distinct feature is required to sustain the distinct properties of PSCs. To date, several studies have reported on the importance of metabolism in PSCs and their derivative cells. Here, we detail advancements in the field, with a focus on cardiac regenerative therapy.

Original languageEnglish
Article number5
JournalInflammation and Regeneration
Volume41
Issue number1
DOIs
Publication statusPublished - 2021 Dec
Externally publishedYes

Keywords

  • Cardiomyocytes
  • Metabolism
  • Pluripotent stem cells
  • Regenerative therapy

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Cell Biology

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