Abstract
For many decades microorganisms have been used for industrial purposes; traditional fermentations such as brewing and production of food additives, aroma molecules, organic acids and pharmaceutical-like antibiotics or recombinant proteins are instances of the industrial microorganism utilization. Therefore, microorganism modeling and simulation have been required for engineering purposes, because of demands for design, optimization and quality control of large-scale fermentation plants. Modeling has recently become more highly developed, aided by the deciphering of microorganism genomes, the completion of metabolic databases, the development of analytical methodologies and improvements in the performance of computers. This paper reviews past and recent metabolic simulation of microorganisms, and also discusses the metabolome analytical techniques and the construction of large-scale microorganism models which are now being developed in our group.
| Original language | English |
|---|---|
| Pages (from-to) | 29-37 |
| Number of pages | 9 |
| Journal | Metabolomics |
| Volume | 1 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2005 Mar |
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Keywords
- Capillary electrophoresis
- Mass spectrometry
- Metabolome
- Microorganism
- Simulation
ASJC Scopus subject areas
- Biochemistry
- Cell Biology
Cite this
Metabolome analysis and metabolic simulation. / Ishii, Nobuyoshi; Soga, Tomoyoshi; Nishioka, Takaaki; Tomita, Masaru.
In: Metabolomics, Vol. 1, No. 1, 03.2005, p. 29-37.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Metabolome analysis and metabolic simulation
AU - Ishii, Nobuyoshi
AU - Soga, Tomoyoshi
AU - Nishioka, Takaaki
AU - Tomita, Masaru
PY - 2005/3
Y1 - 2005/3
N2 - For many decades microorganisms have been used for industrial purposes; traditional fermentations such as brewing and production of food additives, aroma molecules, organic acids and pharmaceutical-like antibiotics or recombinant proteins are instances of the industrial microorganism utilization. Therefore, microorganism modeling and simulation have been required for engineering purposes, because of demands for design, optimization and quality control of large-scale fermentation plants. Modeling has recently become more highly developed, aided by the deciphering of microorganism genomes, the completion of metabolic databases, the development of analytical methodologies and improvements in the performance of computers. This paper reviews past and recent metabolic simulation of microorganisms, and also discusses the metabolome analytical techniques and the construction of large-scale microorganism models which are now being developed in our group.
AB - For many decades microorganisms have been used for industrial purposes; traditional fermentations such as brewing and production of food additives, aroma molecules, organic acids and pharmaceutical-like antibiotics or recombinant proteins are instances of the industrial microorganism utilization. Therefore, microorganism modeling and simulation have been required for engineering purposes, because of demands for design, optimization and quality control of large-scale fermentation plants. Modeling has recently become more highly developed, aided by the deciphering of microorganism genomes, the completion of metabolic databases, the development of analytical methodologies and improvements in the performance of computers. This paper reviews past and recent metabolic simulation of microorganisms, and also discusses the metabolome analytical techniques and the construction of large-scale microorganism models which are now being developed in our group.
KW - Capillary electrophoresis
KW - Mass spectrometry
KW - Metabolome
KW - Microorganism
KW - Simulation
UR - http://www.scopus.com/inward/record.url?scp=22144488101&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=22144488101&partnerID=8YFLogxK
U2 - 10.1007/s11306-005-1105-5
DO - 10.1007/s11306-005-1105-5
M3 - Article
AN - SCOPUS:22144488101
VL - 1
SP - 29
EP - 37
JO - Metabolomics
JF - Metabolomics
SN - 1573-3882
IS - 1
ER -