Metabolome analysis and metabolic simulation

Nobuyoshi Ishii, Tomoyoshi Soga, Takaaki Nishioka, Masaru Tomita

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

For many decades microorganisms have been used for industrial purposes; traditional fermentations such as brewing and production of food additives, aroma molecules, organic acids and pharmaceutical-like antibiotics or recombinant proteins are instances of the industrial microorganism utilization. Therefore, microorganism modeling and simulation have been required for engineering purposes, because of demands for design, optimization and quality control of large-scale fermentation plants. Modeling has recently become more highly developed, aided by the deciphering of microorganism genomes, the completion of metabolic databases, the development of analytical methodologies and improvements in the performance of computers. This paper reviews past and recent metabolic simulation of microorganisms, and also discusses the metabolome analytical techniques and the construction of large-scale microorganism models which are now being developed in our group.

Original languageEnglish
Pages (from-to)29-37
Number of pages9
JournalMetabolomics
Volume1
Issue number1
DOIs
Publication statusPublished - 2005 Mar

Fingerprint

Metabolome
Microorganisms
Fermentation
Food Additives
Recombinant Proteins
Quality Control
Genome
Databases
Anti-Bacterial Agents
Acids
Food additives
Pharmaceutical Preparations
Brewing
Organic acids
Quality control
Genes
Molecules

Keywords

  • Capillary electrophoresis
  • Mass spectrometry
  • Metabolome
  • Microorganism
  • Simulation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology

Cite this

Metabolome analysis and metabolic simulation. / Ishii, Nobuyoshi; Soga, Tomoyoshi; Nishioka, Takaaki; Tomita, Masaru.

In: Metabolomics, Vol. 1, No. 1, 03.2005, p. 29-37.

Research output: Contribution to journalArticle

Ishii, Nobuyoshi ; Soga, Tomoyoshi ; Nishioka, Takaaki ; Tomita, Masaru. / Metabolome analysis and metabolic simulation. In: Metabolomics. 2005 ; Vol. 1, No. 1. pp. 29-37.
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