Metabolome analysis of erythrocytes from patients with chronic hepatitis C reveals the etiology of ribavirin-induced hemolysis

Tetsuru Karasawa, Takafumi Saito, Yoshiyuki Ueno, Masahiro Sugimoto, Tomoyoshi Soga

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Ribavirin is one of the major agents used in combination therapy with interferon for chronic hepatitis C, but is often associated with hemolytic anemia as a serious adverse event. Employing metabolome analysis, we demonstrated that the concentrations of intermediate metabolites produced by glycolysis and the pentose phosphate cycle in patients' erythrocytes were significantly decreased after administration of ribavirin. Our findings suggest that hemolysis associated with ribavirin is triggered by an energy crisis and consequent oxidative stress, thus having implications for the prevention of such hemolysis.

Original languageEnglish
Pages (from-to)1575-1577
Number of pages3
JournalInternational Journal of Medical Sciences
Volume10
Issue number11
DOIs
Publication statusPublished - 2013 Sep 9

Keywords

  • Anemia
  • Glycolysis
  • HCV
  • Metabolome
  • Pentose phosphate cycle
  • Ribavirin

ASJC Scopus subject areas

  • Medicine(all)

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