Meteorin: A secreted protein that regulates glial cell differentiation and promotes axonal extension

Jinsuke Nishino, Kimiyo Yamashita, Hiromi Hashiguchi, Hideta Fujii, Takuya Shimazaki, Hiroshi Hamada

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Glial cells are major components of the nervous system. The roles of these cells are not fully understood, however. We have now identified a secreted protein, designated Meteorin, that is expressed in undifferentiated neural progenitors and in the astrocyte lineage, including radial glia. Meteorin selectively promoted astrocyte formation from mouse cerebrocortical neurospheres in differentiation culture, whereas it induced cerebellar astrocytes to become radial glia. Meteorin also induced axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia. These observations suggest that Meteorin plays important roles in both glial cell differentiation and axonal network formation during neurogenesis.

Original languageEnglish
Pages (from-to)1998-2008
Number of pages11
JournalEMBO Journal
Volume23
Issue number9
DOIs
Publication statusPublished - 2004 May 5

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Neuroglia
Cell Differentiation
Astrocytes
Proteins
Sensory Ganglia
Neurogenesis
Neurology
Cellular Structures
Nervous System
Neurons
Satellites

Keywords

  • Axonal extension
  • Glial differentiation
  • Secreted protein

ASJC Scopus subject areas

  • Genetics
  • Cell Biology

Cite this

Meteorin : A secreted protein that regulates glial cell differentiation and promotes axonal extension. / Nishino, Jinsuke; Yamashita, Kimiyo; Hashiguchi, Hiromi; Fujii, Hideta; Shimazaki, Takuya; Hamada, Hiroshi.

In: EMBO Journal, Vol. 23, No. 9, 05.05.2004, p. 1998-2008.

Research output: Contribution to journalArticle

Nishino, Jinsuke ; Yamashita, Kimiyo ; Hashiguchi, Hiromi ; Fujii, Hideta ; Shimazaki, Takuya ; Hamada, Hiroshi. / Meteorin : A secreted protein that regulates glial cell differentiation and promotes axonal extension. In: EMBO Journal. 2004 ; Vol. 23, No. 9. pp. 1998-2008.
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