Methotrexate-associated intravascular large B-cell lymphoma in a patient with rheumatoid arthritis

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7 Citations (Scopus)

Abstract

Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.

Original languageEnglish
Pages (from-to)1661-1665
Number of pages5
JournalInternal Medicine
Volume55
Issue number12
DOIs
Publication statusPublished - 2016

Fingerprint

B-Cell Lymphoma
Methotrexate
Rheumatoid Arthritis
Withholding Treatment
Lymphoproliferative Disorders
Biological Factors
Lymphoma
Recurrence
Drug Therapy
Therapeutics

Keywords

  • Intravascular lymphoma
  • Methotrexate
  • Rheumatoid arthritis
  • Spontaneous regression

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Methotrexate-associated intravascular large B-cell lymphoma in a patient with rheumatoid arthritis",
abstract = "Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.",
keywords = "Intravascular lymphoma, Methotrexate, Rheumatoid arthritis, Spontaneous regression",
author = "Jun Kikuchi and Yuko Kaneko and Hidenori Kasahara and Katsura Emoto and Akiharu Kubo and Shinichiro Okamoto and Tsutomu Takeuchi",
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T1 - Methotrexate-associated intravascular large B-cell lymphoma in a patient with rheumatoid arthritis

AU - Kikuchi, Jun

AU - Kaneko, Yuko

AU - Kasahara, Hidenori

AU - Emoto, Katsura

AU - Kubo, Akiharu

AU - Okamoto, Shinichiro

AU - Takeuchi, Tsutomu

PY - 2016

Y1 - 2016

N2 - Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.

AB - Intravascular large B-cell lymphoma (IVLBCL) is a rare and clinically aggressive lymphoma with an unfavorable prognosis. We report the case of a 50-year-old woman who was diagnosed with IVLBCL during treatment with methotrexate (MTX) and biologic agents for rheumatoid arthritis. The symptoms showed partial improvement only after the cessation of both treatments. She subsequently received chemotherapy and achieved a complete remission and has remained free of recurrence for 2 years without any further treatment. We herein describe a rare case of IVLBCL which presented with the features of an MTX-associated lymphoproliferative disorder.

KW - Intravascular lymphoma

KW - Methotrexate

KW - Rheumatoid arthritis

KW - Spontaneous regression

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