Methotrexate-associated lymphoproliferative disorder of the stomach presumed to be mucosa-associated lymphoid tissue lymphoma

Sho Ishigaki, Tatsuhiro Masaoka, Hisako Kameyama, Miho Kawaida, Kaori Kameyama, Takehiko Mori, Takanori Kanai

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma.

Original languageEnglish
Pages (from-to)3249-3254
Number of pages6
JournalInternal Medicine
Volume57
Issue number22
DOIs
Publication statusPublished - 2018

Keywords

  • Lymphoproliferative disorder
  • MALT lymphoma
  • Methotrexate
  • Rheumatoid arthritis

ASJC Scopus subject areas

  • Internal Medicine

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