Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma

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Abstract

The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma.

Original languageEnglish
Pages (from-to)3249-3254
Number of pages6
JournalInternal medicine (Tokyo, Japan)
Volume57
Issue number22
DOIs
Publication statusPublished - 2018 Jan 1

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Marginal Zone B-Cell Lymphoma
Lymphoproliferative Disorders
Methotrexate
Stomach
In Situ Hybridization
Rheumatoid Arthritis

Keywords

  • lymphoproliferative disorder
  • MALT lymphoma
  • methotrexate
  • rheumatoid arthritis

ASJC Scopus subject areas

  • Internal Medicine

Cite this

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title = "Methotrexate-associated Lymphoproliferative Disorder of the Stomach Presumed to Be Mucosa-associated Lymphoid Tissue Lymphoma",
abstract = "The number of patients with methotrexate-associated lymphoproliferative disorder (MTX-LPD) is increasing. We describe a case of MTX-LPD of the stomach. After treatment with methotrexate for rheumatoid arthritis, the patient developed left cervical lymphadenopathy and an ulcerative lesion in the stomach, which was presumed to be a mucosa-associated lymphoid tissue (MALT) lymphoma. However, we suspected MTX-LPD, based on the clinical course and the positivity of in situ hybridization for the detection of the Epstein-Barr encoding region. After the cessation of MTX, the left cervical lymphadenopathy and the gastric lesion disappeared. This is first report of gastric MTX-LPD that was presumed to be MALT lymphoma.",
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author = "Sho Ishigaki and Tatsuhiro Masaoka and Hisako Kameyama and Miho Kawaida and Kaori Kameyama and Takehiko Mori and Takanori Kanai",
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AU - Ishigaki, Sho

AU - Masaoka, Tatsuhiro

AU - Kameyama, Hisako

AU - Kawaida, Miho

AU - Kameyama, Kaori

AU - Mori, Takehiko

AU - Kanai, Takanori

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KW - methotrexate

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