Metoclopramide in the diagnosis of pheochromocytoma

Hiroshi Kawabe, Yoshiaki Itaya, Hiromichi Suzuki, Kazuoki Kondo, Takao Saruta

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Cardiovascular and plasma catecholamine responses to metoclopramide (MCP), a dopamine antagonist, were examined in 5 patients with pheochromocytoma, 12 patients with essential hypertension (EHT) and 9 normotensive (NT) subjects who displayed symptoms suggestive of pheochromocytoma on a constant daily intake of 100 mEq sodium and 80 mEq potassium. Significant pressor responses to intravenous doses of 5 mg of MCP, which produced no serious pressor episodes and no other undesirable side effects, were found only in the patients with pheochromocytoma, in contrast to the subjects with EHT and NT who tended to display slight depressor responses. After curative surgery for pheochromocytoma, the MGP-induced pressor effects returned to normal. Furthermore, the enhanced pressor effects of MCP in the patients with pheochromocytoma were associated with increased plasma norepinephrine (NE) concentrations. However, the plasma epinephrine (E) concentrations remained unchanged after the MCP injection. Thus, this dose of MCP appears to be a more suitable vasopressor provocative agent in the pharmacological diagnosis of pheochromocytoma compared to currently used agents.

Original languageEnglish
Pages (from-to)557-566
Number of pages10
Journaljapanese heart journal
Volume26
Issue number4
DOIs
Publication statusPublished - 1985 Jan 1

Keywords

  • Blood pressure
  • Norepinephrine

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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    Kawabe, H., Itaya, Y., Suzuki, H., Kondo, K., & Saruta, T. (1985). Metoclopramide in the diagnosis of pheochromocytoma. japanese heart journal, 26(4), 557-566. https://doi.org/10.1536/ihj.26.557